Formation of the Hydroxyapatite-based Hybrid Materials in Presence of Platelet-Poor Plasma Additive

Ilya Evgen'evich Glazov; Valentina Konstantinovna Krut’ko; Tatiana Viktorovna Safronova; Nikita Aleksandrovich Sazhnev; Natalia Rustemovna Kil'deeva; Roman Alekseevich Vlasov; Olga Nikolaevna Musskaya; Anatoly Iosifovich Kulak

doi:10.20944/preprints202306.0302.v1

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preprints.org > chemistry and materials science > biomaterials > doi: 10.20944/preprints202306.0302.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Formation of the Hydroxyapatite-based Hybrid Materials in Presence of Platelet-Poor Plasma Additive

Ilya Evgen'evich Glazov

^* ,

Valentina Konstantinovna Krut’ko

Tatiana Viktorovna Safronova

Nikita Aleksandrovich Sazhnev

Natalia Rustemovna Kil'deeva

Roman Alekseevich Vlasov

Olga Nikolaevna Musskaya

Anatoly Iosifovich Kulak

Version 1 : Received: 4 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (10:14:48 CEST)

A peer-reviewed article of this Preprint also exists.

Glazov, I.E.; Krut’ko, V.K.; Safronova, T.V.; Sazhnev, N.A.; Kil’deeva, N.R.; Vlasov, R.A.; Musskaya, O.N.; Kulak, A.I. Formation of Hydroxyapatite-Based Hybrid Materials in the Presence of Platelet-Poor Plasma Additive. Biomimetics 2023, 8, 297. Glazov, I.E.; Krut’ko, V.K.; Safronova, T.V.; Sazhnev, N.A.; Kil’deeva, N.R.; Vlasov, R.A.; Musskaya, O.N.; Kulak, A.I. Formation of Hydroxyapatite-Based Hybrid Materials in the Presence of Platelet-Poor Plasma Additive. Biomimetics 2023, 8, 297.

Abstract

Applying of blood biopolymers to regulate the phase composition is promising in designing the hydroxyapatite-based hybrid biomaterials with controllable resorbability. Hybrid materials based on hydroxyapatite and platelet-poor plasma (PPP) were formed in conditions of chemical precipi-tation at pH 11, [Ca2+] / [PO43–] ratio 1.67, PPP volume fraction of 6–24%, maturing time of 4–9 days. Mineral component of the materials was represented as 53% hydroxyapatite / 47% amor-phous calcium phosphate after 4 days of maturation, and 100% hydroxyapatite after 9 days of maturation. Varying PPP content from 6% to 24% provided forming of materials with rather de-fined content of amorphous calcium phosphate and biopolymer component, having desired mor-phology ranging from typical apatitic conglomerates to hybrid apatite-biopolymer fibers. Co-precipitated hybrid materials based on hydroxyapatite and PPP are promising for bone regen-eration in osteoplastic and maxillofacial applications.

Keywords

hybrid material; hydroxyapatite formation; amorphous calcium phosphate; platelet-poor plasma; phase composition

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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