People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope

Bosco Christiano Maciel Da Silva; Lais Teodoro Da Silva; Gustavo Ferminie Hildebrando; Paula Ordonhez Rigato; Luis Fernando de Macedo Brigido; Marcello Mihailenko Chaves Magri; Mariana Amélia Monteiro; Tatiane Assone; Alberto José da Silva Duarte; Jorge Casseb

doi:10.20944/preprints202306.0286.v1

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preprints.org > medicine and pharmacology > epidemiology and infectious diseases > doi: 10.20944/preprints202306.0286.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope

Bosco Christiano Maciel Da Silva

Lais Teodoro Da Silva

Gustavo Ferminie Hildebrando

Paula Ordonhez Rigato

Luis Fernando de Macedo Brigido

Marcello Mihailenko Chaves Magri

Mariana Amélia Monteiro

Tatiane Assone

Alberto José da Silva Duarte

Jorge Casseb

Version 1 : Received: 5 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (09:10:18 CEST)

How to cite: Da Silva, B.C.M.; Da Silva, L.T.; Hildebrando, G.F.; Rigato, P.O.; Brigido, L.F.D.M.; Magri, M.M.C.; Monteiro, M.A.; Assone, T.; Duarte, A.J.D.S.; Casseb, J. People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope. Preprints 2023, 2023060286. https://doi.org/10.20944/preprints202306.0286.v1 Da Silva, B.C.M.; Da Silva, L.T.; Hildebrando, G.F.; Rigato, P.O.; Brigido, L.F.D.M.; Magri, M.M.C.; Monteiro, M.A.; Assone, T.; Duarte, A.J.D.S.; Casseb, J. People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope. Preprints 2023, 2023060286. https://doi.org/10.20944/preprints202306.0286.v1

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MDPI and ACS Style

Da Silva, B.C.M.; Da Silva, L.T.; Hildebrando, G.F.; Rigato, P.O.; Brigido, L.F.D.M.; Magri, M.M.C.; Monteiro, M.A.; Assone, T.; Duarte, A.J.D.S.; Casseb, J. People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope. Preprints 2023, 2023060286. https://doi.org/10.20944/preprints202306.0286.v1

APA Style

Da Silva, B.C.M., Da Silva, L.T., Hildebrando, G.F., Rigato, P.O., Brigido, L.F.D.M., Magri, M.M.C., Monteiro, M.A., Assone, T., Duarte, A.J.D.S., & Casseb, J. (2023). People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope. Preprints. https://doi.org/10.20944/preprints202306.0286.v1

Chicago/Turabian Style

Da Silva, B.C.M., Alberto José da Silva Duarte and Jorge Casseb. 2023 "People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope" Preprints. https://doi.org/10.20944/preprints202306.0286.v1

Abstract

We report the characterization of phenotype, genotype, and functional parameters such as CD4+ T cell, viral load, HIV-1 genotype, class I HLA genotype, CCR5 polymorphism, and IFN-γ producing cells from a cohort of 37 people living with HIV-1 (PLWH) (viremic controllers, were compared those on antiretroviral therapy (ART) from two sites in São Paulo, Brazil. Half the PLWH (51.4%) were classified as viremic controllers (Controller group - CG), compared to 48.6% were on ART. As expected, controllers showed baseline higher levels of CD4+ T cells and nadir compared to those under ART, confirming the ability of HIV-1 controllers to preserve these cells even in the absence of ART. IFN-γ-producing cells showed greater magnitude to the HIV peptides Gag in controllers (p<0.03). Our results demonstrated that HLA protective alleles are associated with strong production of IFN-γ to Gag, Nef and RT epitopes in people living with HIV controllers.

Keywords

Human Immunodeficiency Virus (HIV); Long-Term Non-Progressor (LTNP), Elite Controllers (EC); Viremic Controllers (VC); IFN-γ T cell responses; Human Leukocyte Antigens (HLA)

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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