Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In-Hospital Rehabilitation of Patients with COVID-19: A Retrospective Study with Propensity Score Matching

Version 1 : Received: 2 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (08:06:38 CEST)

How to cite: Konev, S.M.; Koneva, E.S.; Matsonashvili, T.R.; Zhumanova, E.N.; Malyutin, D.S.; Serova, N.S.; Achkasov, E.E.; Semenyakin, I.V.; Lyadov, K.V.; Mandel, I.A.; Yaroshetskiy, A.I. In-Hospital Rehabilitation of Patients with COVID-19: A Retrospective Study with Propensity Score Matching. Preprints 2023, 2023060261. https://doi.org/10.20944/preprints202306.0261.v1 Konev, S.M.; Koneva, E.S.; Matsonashvili, T.R.; Zhumanova, E.N.; Malyutin, D.S.; Serova, N.S.; Achkasov, E.E.; Semenyakin, I.V.; Lyadov, K.V.; Mandel, I.A.; Yaroshetskiy, A.I. In-Hospital Rehabilitation of Patients with COVID-19: A Retrospective Study with Propensity Score Matching. Preprints 2023, 2023060261. https://doi.org/10.20944/preprints202306.0261.v1

Abstract

Background: Early rehabilitation is an important strategy for the treatment of severe diseases. The study aimed to assess the efficacy of early rehabilitation of patients with mild-to-moderate COVID-19. Methods: The retrospective single-center study with propensity score matching. Results: 180 patients (54 (44 - 62.3) yo) divided into three equal groups: 1 - physical exercises; 2 - physical exercises and chest massage in an electrostatic field; 3 - no rehabilitation. The length of stay (LOS) in the hospital in group 1 was 14 (11-15) days, group 2 - 13 (11-15) days, group 3 - 15 (13-18) days, p=0.0026. Physical exercises for patients with CT-1 improved the quality of life, assessed by the EQ-5D questionnaire, by reducing the level of anxiety and depression. The Hazard Ratio (HR) for desaturation (<93%) was 2.34 (95% Confidence Interval (CI) 1.18-4.63) for group 2, p=0.001. The HR for C-reactive protein level above 50 mg/l in patients with CT-2 was 2.33 (95% CI 1.56-3.47), p=0.0001. Conclusions: Rehabilitation programs are safe for СOVID-19-patients; reduce hospital LOS; improve the quality of life. Continuous monitoring of a patient's condition during rehabilitation is essential. ClinicalTrials.gov ID: NCT0580836

Keywords

COVID-19; early rehabilitation; computed tomography; physical exercises; chest massage in an electrostatic field.

Subject

Medicine and Pharmacology, Clinical Medicine

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