Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Prognostic Impact of Non-cardiac Comorbidities on Long-Term Prognosis in Patients with Reduced and Preserved Ejection Fraction Following Acute Myocardial Infarction

Lidija Savić
* ORCID logo ,
Igor Mrdovic
ORCID logo ,
Milika Asanin
ORCID logo ,
Sanja Stankovic
ORCID logo ,
Ratko Lasica
ORCID logo ,
Matić Dragan
ORCID logo ,
Damjan Simic
ORCID logo ,
Gordana Krljanac
ORCID logo
Version 1 : Received: 1 June 2023 / Approved: 2 June 2023 / Online: 2 June 2023 (10:00:09 CEST)

A peer-reviewed article of this Preprint also exists.

Savic, L.; Mrdovic, I.; Asanin, M.; Stankovic, S.; Lasica, R.; Matic, D.; Simic, D.; Krljanac, G. Prognostic Impact of Non-Cardiac Comorbidities on Long-Term Prognosis in Patients with Reduced and Preserved Ejection Fraction following Acute Myocardial Infarction. J. Pers. Med. 2023, 13, 1110. Savic, L.; Mrdovic, I.; Asanin, M.; Stankovic, S.; Lasica, R.; Matic, D.; Simic, D.; Krljanac, G. Prognostic Impact of Non-Cardiac Comorbidities on Long-Term Prognosis in Patients with Reduced and Preserved Ejection Fraction following Acute Myocardial Infarction. J. Pers. Med. 2023, 13, 1110.

Abstract

Background: The prognostic impact of non-cardiac comorbidities can vary in relation to the left ventricular ejection fraction (EF) in patients with ST-elevation myocardial infarction (STEMI). The aim was to analyze prevalence and long-term prognostic impact of non-cardiac co-morbidities in patients with reduced and preserved EF following STEMI. Method: 3115 STEMI patients undergoing primary PCI were divided in two groups: reduced EF <50% and preserved EF≥50%. Follow-up period was 8 years. Results: Preserved EF was present in 1726 (55.4%) patients and reduced EF was present in 1389 (44.5%) patients. Non-cardiac comorbidities were more frequent in patients with reduced EF as compared with patients with preserved EF (38.9% vs 27.4%, respectively, p<0.001). Lethal outcome was registered in 240 (17.2%) patients with reduced EF and in 40 (2.3%) patients with preserved EF, p<0.001. Diabetes and CKD were independent predictors for 8-year mortality in patients with preserved EF while in patients with reduced EF only CKD was independently associated with 8-year mortality. Conclusion: In the present study the prevalence of non-cardiac comorbidities is similar in patients with reduced and preserved EF after STEMI, but only DM and CKD are independently associated with long-term mortality.

Keywords

non-cardiac comorbidities; ejection fraction; myocardial infarction; prognosis

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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