Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Head and Neck Low Grade Chondrosarcoma– A Rare Entity

Version 1 : Received: 31 May 2023 / Approved: 2 June 2023 / Online: 2 June 2023 (03:51:38 CEST)

A peer-reviewed article of this Preprint also exists.

Mireștean, C.C.; Simionescu, C.E.; Iancu, R.I.; Stan, M.C.; Iancu, D.P.T.; Bădulescu, F. Head and Neck Low Grade Chondrosarcoma—A Rare Entity. Diagnostics 2023, 13, 3026. Mireștean, C.C.; Simionescu, C.E.; Iancu, R.I.; Stan, M.C.; Iancu, D.P.T.; Bădulescu, F. Head and Neck Low Grade Chondrosarcoma—A Rare Entity. Diagnostics 2023, 13, 3026.

Abstract

Chondrosarcoma, represents approximately 0.1% of all neoplasms of the head and neck, being considered a rare disease, but with a relatively good prognosis. The 5-year overall survival (OS) rate is estimated at 70-80%, being considered a disease with a low growth rate. About 13% of all cases of chondrosarcoma, are located in the region of the head and neck. We present the case of a young patient treated multimodally, lost from the oncological records less than two years after the diagnosis, without evidence of disease progression. The early loss from the oncological follow-up programs of patients with a lower risk of early repalpse, without evidence of a recurrence or metastasis could be the consequence of a major complication among which we could assume an aspiration pneumonia secondary to a dysphagia, associated with an aggressive multidisciplinary treatment. Large tumor size and positive resection margins (R1 resection) are risk factors that support an intensive adjuvant approach in order to reduce the risk of recurrence, but the low grade of tumor, associating a lower risk of recurrence as well as the adverse events (AE) of adjuvant radiotherapy and chemotherapy justifies a more reserved therapeutic approach. Taking into account the longer life expectancy of these patients, it is recommended to use a more conformal irradiation technique in order to reduce doses to radiosensitive structures as well as to omit elective neck irradiation, taking into account the lower risk of lymph node involvement. The lack of guidelines that include very rare tumors including low grade chondrosarcoma of head and neck make a unified approach difficult, but the data presented even in case reports could contribute to choosing the regimen that offers the best therapeutic ratio.

Keywords

low grade chondrosarcoma; head and neck cancers; radiotherapy; chemotherapy

Subject

Medicine and Pharmacology, Oncology and Oncogenics

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