Nagi, M.; Chapple, I.L.C.; Sharma, P.; Kuehne, S.A.; Hirschfeld, J. Quorum Sensing in Oral Biofilms: Influence on Host Cells. Microorganisms2023, 11, 1688.
Nagi, M.; Chapple, I.L.C.; Sharma, P.; Kuehne, S.A.; Hirschfeld, J. Quorum Sensing in Oral Biofilms: Influence on Host Cells. Microorganisms 2023, 11, 1688.
Nagi, M.; Chapple, I.L.C.; Sharma, P.; Kuehne, S.A.; Hirschfeld, J. Quorum Sensing in Oral Biofilms: Influence on Host Cells. Microorganisms2023, 11, 1688.
Nagi, M.; Chapple, I.L.C.; Sharma, P.; Kuehne, S.A.; Hirschfeld, J. Quorum Sensing in Oral Biofilms: Influence on Host Cells. Microorganisms 2023, 11, 1688.
Abstract
Oral diseases remain a major health problem worldwide, with the World Health Organisation reporting that oral health neglect affects almost half of the world’s population. Quorum sensing molecules (QSMs) influence oral biofilms in various ways with knowledge of direct oral QSM-host interaction being limited, and such studies could provide more insight into the cross-kingdom communication occurring during oral disease development. This review aims to explore the literature on oral QSM-host interaction and to highlight areas of advancement in this field. QSM CSP-1 produced by Gram-positive oral bacteria was found to interact with T2R receptors, activating NF-kB signalling and leading to remodeling of the cytoskeleton. AI-2 in the oral cavity was found in various studies to elicit an inflammatory response in specific oral cells. Overall AHL detection methods remain an area for development, through which greater understanding of oral QSMs’ influence on host cells can be achieved. In conclusion, from the current literature it can be inferred that that QSMs are utilised by host cells to detect bacterial presence and in the majority of cases elicit an immune response towards the environmental QSMs. This may provide a base to target QSMs as novel treatment of oral diseases.
Medicine and Pharmacology, Dentistry and Oral Surgery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
