Version 1
: Received: 30 May 2023 / Approved: 1 June 2023 / Online: 1 June 2023 (03:10:51 CEST)
How to cite:
Riaz, M.A.; Mecha, E.O.; Omwandho, C.O.A.; Zeppernick, F.; Meinhold-Heerlein, I.; Konrad, L. Expression Differences Between the Eutopic Endometrium With and Without Endometriosis and the Ectopic Endome-trium. A Re-Analysis of Arrays. Preprints2023, 2023060009. https://doi.org/10.20944/preprints202306.0009.v1
Riaz, M.A.; Mecha, E.O.; Omwandho, C.O.A.; Zeppernick, F.; Meinhold-Heerlein, I.; Konrad, L. Expression Differences Between the Eutopic Endometrium With and Without Endometriosis and the Ectopic Endome-trium. A Re-Analysis of Arrays. Preprints 2023, 2023060009. https://doi.org/10.20944/preprints202306.0009.v1
Riaz, M.A.; Mecha, E.O.; Omwandho, C.O.A.; Zeppernick, F.; Meinhold-Heerlein, I.; Konrad, L. Expression Differences Between the Eutopic Endometrium With and Without Endometriosis and the Ectopic Endome-trium. A Re-Analysis of Arrays. Preprints2023, 2023060009. https://doi.org/10.20944/preprints202306.0009.v1
APA Style
Riaz, M.A., Mecha, E.O., Omwandho, C.O.A., Zeppernick, F., Meinhold-Heerlein, I., & Konrad, L. (2023). Expression Differences Between the Eutopic Endometrium With and Without Endometriosis and the Ectopic Endome-trium. A Re-Analysis of Arrays. Preprints. https://doi.org/10.20944/preprints202306.0009.v1
Chicago/Turabian Style
Riaz, M.A., Ivo Meinhold-Heerlein and Lutz Konrad. 2023 "Expression Differences Between the Eutopic Endometrium With and Without Endometriosis and the Ectopic Endome-trium. A Re-Analysis of Arrays" Preprints. https://doi.org/10.20944/preprints202306.0009.v1
Abstract
In the pathogenesis of endometriosis, the differences between the eutopic and ectopic endometrium as well as between the eutopic endometrium with and without endometriosis are repeatedly pointed out. Various mechanisms have been suggested to explain these changes among them epithelial-mesenchymal transition (EMT). Recently, we suggested based on immunohistochemical data that most of the changes occur after and not before implantation of endometrial cells into ectopic locations. Furthermore, the subtle changes between eutopic endometrium with and without endometriosis and maintenance of epithelial cell-to cell contacts only suggest a partial EMT. In this study, we have re-analyzed the mRNA expression array data of eutopic and ectopic endometrium with respect to expression changes and EMT. Especially, we found that the similarity between eutopic endometrium with and without endometriosis is extremely high (~99.1%). In contrast, eutopic endometrium compared to ectopic endometrium only shows an overall similarity of ~95.3%. Analysis of some EMT-associated genes revealed small differences in the mRNA expression levels of some members of the claudin family. The array data suggest that the changes in eutopic endometrium at the beginning of the disease are quite subtle and that the majority of differences occur after implantation into ectopic locations.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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