Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Importance of Neutrophils in Osteoarthritis: Current Concepts and Therapeutic Perspectives

Yeganeh Mehrani
* ORCID logo ,
Rasool Rahimi
,
Solmaz Morovati
ORCID logo ,
Hossein Mehrani
,
Negar Karimi
ORCID logo ,
Samaneh Ghasemi
* ORCID logo
Version 1 : Received: 30 May 2023 / Approved: 31 May 2023 / Online: 31 May 2023 (12:55:03 CEST)

A peer-reviewed article of this Preprint also exists.

Mehrani, Y.; Rahimi Junqani, R.; Morovati, S.; Mehrani, H.; Karimi, N.; Ghasemi, S. The Importance of Neutrophils in Osteoarthritis: Current Concepts and Therapeutic Perspectives. Immuno 2023, 3, 250-272. Mehrani, Y.; Rahimi Junqani, R.; Morovati, S.; Mehrani, H.; Karimi, N.; Ghasemi, S. The Importance of Neutrophils in Osteoarthritis: Current Concepts and Therapeutic Perspectives. Immuno 2023, 3, 250-272.

Abstract

Osteoarthritis (OA) is the most common degenerative joint disease that causes chronic pain and disability. Different innate immune components, including macrophages, T cells, and neutrophils, participate in osteoarthritis pathophysiology. Neutrophils are the most abundant circulating leukocytes with multiple specialized functions contributing to innate and adaptive immune functions. Although neutrophils produce proinflammatory cytokines and chemokines, reactive oxygen species (ROS), matrix-degrading enzymes, and neutrophil extracellular traps (NET) that promote joint degradation as the first recruit cells in an inflamed joint, these cells also play an important role in joint repair by regulating the immune response, releasing anti-inflammatory factors, and activating some protective genes. In this review, various aspects of neutrophil biology, their role in inflammation and its association with osteoarthritis, and possible therapeutic approaches to target neutrophils for the treatment of osteoarthritis are described. Understanding neutrophil heterogeneity and their mechanisms of action in joint inflammation, provides a potential strategy for OA management.

Keywords

Keywords: Osteoarthritis, Neutrophil, Innate Immunity, Neutrophil Extracellular Traps (NET).

Subject

Medicine and Pharmacology, Veterinary Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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