Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Interplay between Histone Modifiers and p53 in Regulating Gene Expression

Version 1 : Received: 29 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (11:14:08 CEST)

A peer-reviewed article of this Preprint also exists.

Kim, H.-M.; Zheng, X.; Lee, E. Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression. Int. J. Mol. Sci. 2023, 24, 11032. Kim, H.-M.; Zheng, X.; Lee, E. Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression. Int. J. Mol. Sci. 2023, 24, 11032.

Abstract

Chromatin structure plays a fundamental role in regulating gene expression, with histone modifiers shaping the structure of chromatin by adding or removing chemical changes to his-tone proteins. The p53 transcription factor controls gene expression, binds target genes, and regulates their activity. While p53 has been extensively investigated in the context of cancer research, its association with histone modifiers has received limited attention. This review ex-plores the interplay between histone modifiers and p53 in regulating gene expression. We discussed how histone modifications can influence how p53 binds to target genes and how this interplay can be disrupted in cancer cells. This study provides insights into the complex mechanisms underlying gene regulation and their implications for potential cancer therapy.

Keywords

Histone modifications; p53; cancer; gene regulation; chromatin structure

Subject

Biology and Life Sciences, Cell and Developmental Biology

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