Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Does Iodine Intake Play a Role in Modifying the Relationship between Maternal Dysglycemia and Birth Weight?

Yaniv S. Ovadia
* ORCID logo ,
Dov Gefel
,
Yoel Toledano
,
Shani Rosen
ORCID logo ,
Yael Avrahami-Benyounes
,
Ludmila Groisman
,
Efrat Rorman
,
Lihi Hen
,
Shlomo Fytlovich
,
Liora S Katz
ORCID logo ,
Eyal Y Anteby
,
Simon Shenhav
Version 1 : Received: 27 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (04:08:48 CEST)

A peer-reviewed article of this Preprint also exists.

Ovadia, Y.S.; Gefel, D.; Toledano, Y.; Rosen, S.R.; Avrahami-Benyounes, Y.; Groisman, L.; Rorman, E.; Hen, L.; Fytlovich, S.; Katz, L.S.; Anteby, E.Y.; Shenhav, S. Does Iodine Intake Modify the Effect of Maternal Dysglycemia on Birth Weight in Mild-to-Moderate Iodine-Deficient Populations? A Mother–Newborn Prospective Cohort Study. Nutrients 2023, 15, 2914. Ovadia, Y.S.; Gefel, D.; Toledano, Y.; Rosen, S.R.; Avrahami-Benyounes, Y.; Groisman, L.; Rorman, E.; Hen, L.; Fytlovich, S.; Katz, L.S.; Anteby, E.Y.; Shenhav, S. Does Iodine Intake Modify the Effect of Maternal Dysglycemia on Birth Weight in Mild-to-Moderate Iodine-Deficient Populations? A Mother–Newborn Prospective Cohort Study. Nutrients 2023, 15, 2914.

Abstract

It is unclear how maternal glycemic status and maternal iodine status influence birth weight in mild-to-moderate iodine deficiency (ID). We studied the association between birth weight and both maternal glucose levels and iodine intake in pregnant women with mild-to-moderate ID. Glucose values were assessed using a glucose challenge test (GCT), non-fasting glucose before delivery; iodine status was assessed using an iodine food frequency questionnaire, serum thyroglobulin (Tg) and urinary iodine concentrations (UIC). Thyroid antibodies and free thyroxine (FT4) were measured. Obstetric and an-thropometric data were also collected. Large for gestational age (LGA) was predicted using a Cox proportional hazards model with multiple confounders. Tg>13g/L was in-dependently associated with LGA (adjusted hazard ratio = 3.4, 95% CI: 1.4–10.2, p=0.001). Estimated iodine intake correlated with FT4 among participants reporting io-dine-containing supplements (ICS) after adjusting for confounders (β = 0.4 95 %CI: 0.0002-0.0008, p=0.001). Newborn weight percentiles were inversely correlated with maternal FT4 values (β=-0.2 95 %CI:-0.08 - -56.49, p=0.049). We conclude that in mild-to-moderate ID regions, maternal insufficient iodine status may increase LGA risk. Iodine status and ICS intake may modify the effect maternal dysglycemia has on offspring weight.

Keywords

iodine deficiency; glucose challenge test; large for gestational age; thyroglobulin; io-dine-containing supplements; maternal dysglycemia

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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