Review
Version 1
Preserved in Portico This version is not peer-reviewed
Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer
Version 1
: Received: 24 May 2023 / Approved: 25 May 2023 / Online: 25 May 2023 (09:52:24 CEST)
A peer-reviewed article of this Preprint also exists.
Jerin, S.; Harvey, A.J.; Lewis, A. Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer. Cancers 2023, 15, 3703. Jerin, S.; Harvey, A.J.; Lewis, A. Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer. Cancers 2023, 15, 3703.
Abstract
PTK6, a Non-Receptor–Tyrosine-Kinase, modulates the pathogenesis of breast and prostate cancers, and is recognized as a biomarker of breast cancer prognosis. There are over 30 known substrates of PTK6, including signal transducers, transcription factors and RNA binding proteins. Many of these substrates are known drivers of other cancer types such as colorectal cancer. Colon and rectal tumours also express higher levels of PTK6 than the normal intestine suggesting a potential role in tumorigenesis. However, the importance of PTK6 in colorectal cancer remains unclear. PTK6 inhibitors such as XMU-MP-2 and Tilfrinib have demonstrated potency and selectivity in breast cancer cells when used in combination with chemotherapy, indicating the potential for PTK6 targeted therapy in cancer. However, most of these inhibitors are yet to be tested in other cancer types. Here, we discuss the current understanding of the function of PTK6 in normal intestinal cells compared with colorectal cancer cells. We review existing PTK6 targeting therapeutics and explore the possibility of PTK6 inhibitory therapy for colorectal cancer.
Keywords
PTK6; Colorectal cancer; Tyrosine Kinase Inhibitors
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
