Bicsko, R.R.; Antal, L.; Magyari, F.; Szász, R.; Udvardy, M.; Illes, A.; Gergely, L. Autologous Transplantation May Still Effectively Treat Relapsed Diffuse Large B-Cell Lymphoma in Selected Patients. Cancers2023, 15, 3223.
Bicsko, R.R.; Antal, L.; Magyari, F.; Szász, R.; Udvardy, M.; Illes, A.; Gergely, L. Autologous Transplantation May Still Effectively Treat Relapsed Diffuse Large B-Cell Lymphoma in Selected Patients. Cancers 2023, 15, 3223.
Bicsko, R.R.; Antal, L.; Magyari, F.; Szász, R.; Udvardy, M.; Illes, A.; Gergely, L. Autologous Transplantation May Still Effectively Treat Relapsed Diffuse Large B-Cell Lymphoma in Selected Patients. Cancers2023, 15, 3223.
Bicsko, R.R.; Antal, L.; Magyari, F.; Szász, R.; Udvardy, M.; Illes, A.; Gergely, L. Autologous Transplantation May Still Effectively Treat Relapsed Diffuse Large B-Cell Lymphoma in Selected Patients. Cancers 2023, 15, 3223.
Abstract
Treating relapsed and refractory diffuse large B-cell lymphoma is still challenging for clinicians, but the available CAR-T and bispecific antibodies revolutionized therapy. Autologous stem cell transplantation was the most effective treatment modality previously. The authors report data from a single center over ten years. The retrospective study included 116 patients. There were 53 relapsed, 39 primary refractory cases, 19 had CNS involvement, and 5 received primary consolidation transplants. The median duration of follow-up was 46 months. The median event-free survival was 75 months, and the median overall survival was 105 months for all cases. Five-year overall survival was 59%, and event-free survival was 54%. Pretreatment prognostic factors at diagnosis had no effect on the outcome of transplantation. The authors found no difference between survival in relapsed or refractory cases, and the number of salvage lines or the germinal center / activated B-cell type also did not influence the results. Complete metabolic response before transplant confirmed by 18FDG PET/CT strongly affected survival. The pretransplant creatinine and CRP levels significantly influenced the long-term outcome. The number of stem cells infused did not affect survival, but engraftment within nine days did result in better survival. These data support the finding that the response to salvage therapy did select a better prognostic group who may still benefit from autologous transplantation.
Keywords
diffuse large B-cell lymphoma; relapsed; refractory; autologous stem cell transplantation
Subject
Medicine and Pharmacology, Hematology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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