Version 1
: Received: 18 May 2023 / Approved: 19 May 2023 / Online: 19 May 2023 (10:54:34 CEST)
How to cite:
Zhang, T.; Zhou, Y.; Zhang, X.; Wang, J. Perturbations of Gut Microbiota Compositions in Autism Spectrum Disorder: A Review and Meta-analysis. Preprints2023, 2023051435. https://doi.org/10.20944/preprints202305.1435.v1
Zhang, T.; Zhou, Y.; Zhang, X.; Wang, J. Perturbations of Gut Microbiota Compositions in Autism Spectrum Disorder: A Review and Meta-analysis. Preprints 2023, 2023051435. https://doi.org/10.20944/preprints202305.1435.v1
Zhang, T.; Zhou, Y.; Zhang, X.; Wang, J. Perturbations of Gut Microbiota Compositions in Autism Spectrum Disorder: A Review and Meta-analysis. Preprints2023, 2023051435. https://doi.org/10.20944/preprints202305.1435.v1
APA Style
Zhang, T., Zhou, Y., Zhang, X., & Wang, J. (2023). Perturbations of Gut Microbiota Compositions in Autism Spectrum Disorder: A Review and Meta-analysis. Preprints. https://doi.org/10.20944/preprints202305.1435.v1
Chicago/Turabian Style
Zhang, T., Xuechao Zhang and Juan Wang. 2023 "Perturbations of Gut Microbiota Compositions in Autism Spectrum Disorder: A Review and Meta-analysis" Preprints. https://doi.org/10.20944/preprints202305.1435.v1
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with high heterogeneity and has a prevalence of 0.7% to 3.2% in children. Gut microbiota are a collection of microorganisms that inhabit in human guts, which can produce various metabolites that affect the homeostasis and functions of nervous and endocrine systems. There are many studies on the relationship between various gut microbiota and ASD, but the alteration pattern of microbial profiles in ASD children is not conclusive. In order to more robustly describe the deregulations of gut microbiota compositions in ASD, a meta-analysis was performed. The related investigations from PubMed, Embase and Web of Science were collected and manually reviewed. By procedure, 26 eligible studies until 2023, with a total of 1021 ASD and 951 typically developed children and adolescents, were included for the meta-analysis. RevMan5.4 was used to assess the overall effect of 8 microbes at the phylum level and 19 microbes at the genus level. Results demonstrated relatively up-regulated abundance of Bacteroidetes, Verrucomicrobia, Bacteroides, Clostridium, Dorea and Sutterella, and down-regulated abundance of Proteobacteria, Bifidobacterium, Coprococcus, and Akkermansia in ASD children, indicating partly agreement in the ASD-associated microbes, albeit the heterogeneity of ASD.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
