Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Epstein-Barr Virus Salivary Shedding in Patients With Acute Infectious Diseases – A Pilot Study

Tomislava Skuhala
ORCID logo ,
Snježana Židovec-Lepej
* ORCID logo ,
Vladimir Trkulja
,
Leona Radmanić
ORCID logo ,
Oktavija Đaković-Rode
ORCID logo ,
Bruno Špiljak
ORCID logo ,
Luka Šimunović
,
Marin Rimac
,
Anja Dragobratović
Version 1 : Received: 9 May 2023 / Approved: 10 May 2023 / Online: 10 May 2023 (09:07:35 CEST)

How to cite: Skuhala, T.; Židovec-Lepej, S.; Trkulja, V.; Radmanić, L.; Đaković-Rode, O.; Špiljak, B.; Šimunović, L.; Rimac, M.; Dragobratović, A. Epstein-Barr Virus Salivary Shedding in Patients With Acute Infectious Diseases – A Pilot Study. Preprints 2023, 2023050719. https://doi.org/10.20944/preprints202305.0719.v1 Skuhala, T.; Židovec-Lepej, S.; Trkulja, V.; Radmanić, L.; Đaković-Rode, O.; Špiljak, B.; Šimunović, L.; Rimac, M.; Dragobratović, A. Epstein-Barr Virus Salivary Shedding in Patients With Acute Infectious Diseases – A Pilot Study. Preprints 2023, 2023050719. https://doi.org/10.20944/preprints202305.0719.v1

Abstract

Epstein-Barr virus (EBV) is a widely disseminated herpesvirus for which antibodies have been demonstrated in over 90% of adults worldwide. After subclinical primary EBV infections, as well as after infectious mononucleosis, the virus can be shed in saliva for a prolonged period of time. Diseases and disorders that can induce EBV salivary shedding include mental disorders and sex, connective tissue disease, multiple sclerosis, systemic lupus erythematosus, malaria and HIV infection. As the occurrence of EBV in saliva during acute infectious diseases has not been systematically researched so far, this pilot cross-sectional study aimed to investigate the possible relationship between acute infectious diseases and salivary shedding of EBV. A total of 40 patients with acute infectious diseases was enrolled, along with 41 adults free of acute infections. Peripheral venous blood samples for serodiagnosis and saliva samples for EBV PCR testing were collected from both groups. The most common acute infectious disease was COVID-19 pneumonia, followed by haemorrhagic fever with renal syndrome. Crude proportions of people with positive serological test results and those with saliva viral shedding were similar in the two groups. The presented preliminary data does not indicate acute infectious conditions as a marked “contributor” in increasing salivary EBV shedding.

Keywords

Epstein-Barr virus; acute infectious diseases; salivary shedding

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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