Version 1
: Received: 8 May 2023 / Approved: 9 May 2023 / Online: 9 May 2023 (08:38:24 CEST)
Version 2
: Received: 10 May 2023 / Approved: 11 May 2023 / Online: 11 May 2023 (04:34:03 CEST)
How to cite:
Papageorgiou, S. A Model That Reproduces an Empirical Rule Distinguishing the Developmental Path of Complete Hox Gene Clusters From Split Clusters. Preprints2023, 2023050607. https://doi.org/10.20944/preprints202305.0607.v2
Papageorgiou, S. A Model That Reproduces an Empirical Rule Distinguishing the Developmental Path of Complete Hox Gene Clusters From Split Clusters. Preprints 2023, 2023050607. https://doi.org/10.20944/preprints202305.0607.v2
Papageorgiou, S. A Model That Reproduces an Empirical Rule Distinguishing the Developmental Path of Complete Hox Gene Clusters From Split Clusters. Preprints2023, 2023050607. https://doi.org/10.20944/preprints202305.0607.v2
APA Style
Papageorgiou, S. (2023). A Model That Reproduces an Empirical Rule Distinguishing the Developmental Path of Complete Hox Gene Clusters From Split Clusters. Preprints. https://doi.org/10.20944/preprints202305.0607.v2
Chicago/Turabian Style
Papageorgiou, S. 2023 "A Model That Reproduces an Empirical Rule Distinguishing the Developmental Path of Complete Hox Gene Clusters From Split Clusters" Preprints. https://doi.org/10.20944/preprints202305.0607.v2
Abstract
Abstract: Hox gene clusters are crucial in Embryogenesis. It was observed that some Hox genes were located in order along the telomeric to centromeric direction of the DNA sequence: Hox1, Hox2, Hox3…. These genes were expressed in the same order in the ontogenetic units of the Drosophila embryo along the Anterior-Posterior axis. The two entities (genome and embryo) differ significantly in linear size and in-between distance. This strange phenomenon was named Spatial Collinearity (SP). Later, it was observed that, particularly in the Vertebrates, a Temporal Collinearity (TC) coexists: first is Hox1 expressed, later Hox2 and even later Hox3,…,. Hox clusters are irreversibly elongated along the force direction. According to a Biophysical Model (BM), pulling forces act at the anterior end of the cluster while a cluster fastening applies at the posterior end. During Evolution, the elongated Hox clusters are broken at variable lengths thus split clusters may be created. An Empirical Rule was formulated distinguishing development due to a complete Hox cluster from development due to split Hox clusters. BM can explain this Empirical Rule. In an accidental mutation where the cluster fastening is dismantled, a minimal pulling force can automatically shift the cluster inside the Hox activation domain. This cluster translocation can probably explain the absence of temporal collinearity in Drosophila.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
11 May 2023
Commenter:
Spyros Papageorgiou
Commenter's Conflict of Interests:
Author
Comment:
p.11 line 6 from bottom: CF may be attractive if Q1 is negative and Q2 positive or repulsive if both Q1 and Q2 are either positive or negative.
Commenter: Spyros Papageorgiou
Commenter's Conflict of Interests: Author