Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Persistence of SARS-Cov-2 Igg Antibody Response among South African Adults: A Prospective Cohort Study

Version 1 : Received: 4 May 2023 / Approved: 8 May 2023 / Online: 8 May 2023 (03:29:35 CEST)

A peer-reviewed article of this Preprint also exists.

Adeniyi, O.V.; Durojaiye, O.C.; Masilela, C. Persistence of SARS-CoV-2 IgG Antibody Response among South African Adults: A Prospective Cohort Study. Vaccines 2023, 11, 1068. Adeniyi, O.V.; Durojaiye, O.C.; Masilela, C. Persistence of SARS-CoV-2 IgG Antibody Response among South African Adults: A Prospective Cohort Study. Vaccines 2023, 11, 1068.

Abstract

This study assesses the durability of severe acute respiratory coronavirus-2 (SARS-CoV-2) anti-nucleocapsid (anti-N) immunoglobulin G (IgG) after infection, and examines its association with established risk factors among South African healthcare workers (HCWs). Blood samples were obtained from 390 HCWs with diagnosis of coronavirus disease 2019 (COVID-19) for assay of the SARS-CoV-2 anti-N IgG at two time points (Phase 1 & 2) between November 2020 and February 2021. Out of 390 HCWs with COVID-19 diagnosis, 267 (68.5%) had detectable SARS-CoV-2 anti-N IgG antibodies at the end of phase I. These antibodies persisted for 4-5 and 6-7 months in 76.4% and 16.1%, respectively. In the multivariate logistic regression model analysis, black participants were more likely to sustain SARS-CoV-2 anti-N IgG for 4-5 months. However, participants who were HIV positive were less likely to sustain SARS-CoV-2 anti-N IgG antibodies for 4-5 months. In addition, individuals who were <45 years of age were more likely to sustain SARS-CoV-2 anti-N IgG for 6-7 months. Of the 202 HCWs selected for phase 2, 116 participants (57.4%) had persistent SARS-CoV-2 anti-N IgG for an extended mean period of 223 days (7.5 months). Findings support the longevity of vaccine responses against SARS CoV-2 in black Africans.

Keywords

SARS-CoV-2; COVID-19; Humoral immune response; Persistence; South Africa

Subject

Public Health and Healthcare, Public, Environmental and Occupational Health

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