Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry

These authors contributed equally to this work as first authors.
These authors contributed equally to this work as last authors.
Version 1 : Received: 4 May 2023 / Approved: 5 May 2023 / Online: 5 May 2023 (11:00:26 CEST)

A peer-reviewed article of this Preprint also exists.

Bellocchio, L.; Patano, A.; Inchingolo, A.D.; Inchingolo, F.; Dipalma, G.; Isacco, C.G.; de Ruvo, E.; Rapone, B.; Mancini, A.; Lorusso, F.; Scarano, A.; Malcangi, G.; Inchingolo, A.M. Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry. Int. J. Mol. Sci. 2023, 24, 9693. Bellocchio, L.; Patano, A.; Inchingolo, A.D.; Inchingolo, F.; Dipalma, G.; Isacco, C.G.; de Ruvo, E.; Rapone, B.; Mancini, A.; Lorusso, F.; Scarano, A.; Malcangi, G.; Inchingolo, A.M. Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry. Int. J. Mol. Sci. 2023, 24, 9693.

Abstract

The medical use of Cannabis has a very long history. Although many principles are present in cannabis, called cannabinoids, Δ9tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD) and can-nabinol (CBN) are the three main cannabinoids most present and described. CBD itself is not re-sponsible for psychotropic effects of cannabis since does not produce the typical behavioral effects associated to the consumption of this drug. Cannabidiol (CBD) has recently gained growing at-tention in modern society and seems to be more and more explored in dentistry. Several subjective findings suggest some therapeutic effects of CBD, which are strongly supported by research evi-dence. However, there is a plethora of data regarding CBD’s mechanism of action and therapeutic potential, which are in many cases contradictory. We will first provide an overview of scientific evidence on the molecular mechanism of CBD’s action. Furthermore, we will map the recent de-velopments regarding possible oral benefits of CBD. In summary, we will highlight CBD’s prom-ising biological features for dentistry application, despite exiting patents suggest current the compositions for oral care as the main interest for industry.

Keywords

plants; cannabinoids; CBD; pharmacology; dental medicine; patents

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

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