Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Study of Gastric Fluid and Urine Metabolomics for the Prediction of Survival in Severe Prematurity

Konstantia Besiri
,
Olga Begou
,
Olga Deda
ORCID logo ,
Evmorfia Bataka
,
Christos Nakas
,
Helen Gika
ORCID logo ,
Angeliki Kontou
ORCID logo ,
Eleni Agakidou
ORCID logo ,
Kosmas Sarafidis
* ORCID logo
Version 1 : Received: 3 May 2023 / Approved: 4 May 2023 / Online: 4 May 2023 (05:21:26 CEST)

A peer-reviewed article of this Preprint also exists.

Besiri, K.; Begou, O.; Deda, O.; Bataka, E.; Nakas, C.; Gika, H.; Kontou, A.; Agakidou, E.; Sarafidis, K. A Cohort Study of Gastric Fluid and Urine Metabolomics for the Prediction of Survival in Severe Prematurity. Metabolites 2023, 13, 708. Besiri, K.; Begou, O.; Deda, O.; Bataka, E.; Nakas, C.; Gika, H.; Kontou, A.; Agakidou, E.; Sarafidis, K. A Cohort Study of Gastric Fluid and Urine Metabolomics for the Prediction of Survival in Severe Prematurity. Metabolites 2023, 13, 708.

Abstract

Prediction of survival in very preterm infants is very important in terms of clinical medicine and parent counseling. In this prospective study involving 96 very preterm infants, we evaluated whether metabolomic analysis of gastric fluid and urine samples obtained soon after birth could predict survival on days of life (DOL) 3 and 15 as well as overall survival up to hospital discharge. Gas chromatography-mass spectrometry (GC-MS) profiling was used. Uni- and multivariate statistical analyses were carried out to evaluate significant metabolites and their prognostic value. Differences in several metabolites were identified between survivors and non-survivors at the time-points of the study. Binary logistic regression showed that certain metabolites in the gastric fluid including arabitol as well as succinic, erythronic and threonic acids was associated with DOL 15 and overall survival. Gastric glyceric acid was also associated with DOL 15 survival. Urine glyceric acid could predict survival on DOL 3 and overall survival. In conclusion, non-surviving preterm infants showed a different metabolic profile compared survivors showing a significant discrimination with the use of GC-MS-based gastric fluid and urine analysis. Results of this study support the usefulness of metabolomics in developing survival biomarkers in very preterm infants.

Keywords

gastric fluid; urine; metabolite; GC-MS; prematurity; survival

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Supplementary Files Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.