Jorgenson MC, Aguree S, Schalinske KL, Reddy MB. Effects of green tea polyphenols on inflammation and iron status. Journal of Nutritional Science. 2023;12:e119. doi:10.1017/jns.2023.107
Jorgenson MC, Aguree S, Schalinske KL, Reddy MB. Effects of green tea polyphenols on inflammation and iron status. Journal of Nutritional Science. 2023;12:e119. doi:10.1017/jns.2023.107
Jorgenson MC, Aguree S, Schalinske KL, Reddy MB. Effects of green tea polyphenols on inflammation and iron status. Journal of Nutritional Science. 2023;12:e119. doi:10.1017/jns.2023.107
Jorgenson MC, Aguree S, Schalinske KL, Reddy MB. Effects of green tea polyphenols on inflammation and iron status. Journal of Nutritional Science. 2023;12:e119. doi:10.1017/jns.2023.107
Abstract
Inflammation is an underlying problem for many disease states and has been implicated in iron deficiency (ID). This study aimed to determine whether iron status is improved by epigallocate-chin-3-gallate (EGCG) through reducing inflammation. Thirty-two male Sprague-Dawley rats were randomly divided into four groups (n = 8 each): positive controls, negative controls, lipo-polysaccharide (LPS, 0.5 mg/kg body weight), and LPS + EGCG (LPS plus 600 mg EGCG/kg diet). Iron status, hepcidin, C - reactive protein (CRP), serum amyloid A (SAA), and interleukin-6 (IL-6) were measured. There were no differences in treatment groups compared with control in CRP, hepcidin, and liver iron concentrations. Serum iron concentrations were significantly lower in the LPS (p=0.02) and the LPS+EGCG (p=0.01) than in the positive control group. Compared to the positive control group, spleen iron concentrations were significantly lower in the negative con-trol (p<0.001) but not with both LPS groups. SAA concentrations were significantly lower in LPS + EGCG group compared to LPS alone group. IL-6 concentrations were significantly higher in LPS+EGCG (p= 0.004) than in any of the three groups. EGCG reduced SAA concentrations but did not affect hepcidin or improve serum iron concentration or other iron markers.
Keywords
Iron; inflammation; EGCG; hepcidin
Subject
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
