Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells

Kinga Anna Urbanek
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Karolina Kowalska
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Dominika Ewa Habrowska-Górczyńska
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Marta Justyna Kozieł
* ORCID logo ,
Kamila Domińska
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Agnieszka Wanda Piastowska-Ciesielska
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Version 1 : Received: 30 April 2023 / Approved: 1 May 2023 / Online: 1 May 2023 (11:08:44 CEST)

A peer-reviewed article of this Preprint also exists.

Urbanek, K.A.; Kowalska, K.; Habrowska-Górczyńska, D.E.; Kozieł, M.J.; Domińska, K.; Piastowska-Ciesielska, A.W. Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells. Int. J. Mol. Sci. 2023, 24, 9513. Urbanek, K.A.; Kowalska, K.; Habrowska-Górczyńska, D.E.; Kozieł, M.J.; Domińska, K.; Piastowska-Ciesielska, A.W. Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells. Int. J. Mol. Sci. 2023, 24, 9513.

Abstract

The mycotoxin alternariol (AOH) can be found in the food products infected by Alternaria spp. and is considered an endocrine-disruptive mycotoxin. The main mechanism of AOH toxicity is associated with DNA damage and modulation of the inflammation process. Nevertheless, AOH is considered as one of the emerging mycotoxins. In this study we evaluated how AOH might affect a local steroidogenesis process in prostate, in both normal as well as cancer cells. We observed that AOH itself modulates the cell cycle, inflammation and apoptosis rather than steroidogenesis process in prostate cancer cells; however, in the presence of the other steroidogenic agent, the effect is significant. Therefore, this is the first study to report the effect of AOH on local steroidogenesis in normal and prostate cancer cells. We postulate that AOH might modulate the release of the steroid hormones and expression of the key components by interfering with the steroidogenic pathway and might be considered a steroidogenesis-altering agent.

Keywords

alternariol, steroidogenesis, mycotoxin, carcinogenesis, dehydroepiandrosterone

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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