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Seroepidemiological and Molecular Survey for Detection of SARS-CoV-2 Infection Among Children in Iran, September 2020 to June 2021: One-Year Cross-sectional Study
Mansour Ghanaie, R.; Boone, I.; Shamshiri, A.R.; Karimi, A.; Amirali, A.; Marhamati, N.; Rostami, M.H.; Pashaei, N.; Janbazi, S.; Azimi, L.; Khodaei, H.; Fallah, F.; Eckmanns, T.; Jansen, A.; Baradaran, H.R.; Momeny Ourimi, M.; Maham, S.; Elikaei, A.; Alebouyeh, M. Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study. Microorganisms2023, 11, 1672.
Mansour Ghanaie, R.; Boone, I.; Shamshiri, A.R.; Karimi, A.; Amirali, A.; Marhamati, N.; Rostami, M.H.; Pashaei, N.; Janbazi, S.; Azimi, L.; Khodaei, H.; Fallah, F.; Eckmanns, T.; Jansen, A.; Baradaran, H.R.; Momeny Ourimi, M.; Maham, S.; Elikaei, A.; Alebouyeh, M. Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study. Microorganisms 2023, 11, 1672.
Mansour Ghanaie, R.; Boone, I.; Shamshiri, A.R.; Karimi, A.; Amirali, A.; Marhamati, N.; Rostami, M.H.; Pashaei, N.; Janbazi, S.; Azimi, L.; Khodaei, H.; Fallah, F.; Eckmanns, T.; Jansen, A.; Baradaran, H.R.; Momeny Ourimi, M.; Maham, S.; Elikaei, A.; Alebouyeh, M. Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study. Microorganisms2023, 11, 1672.
Mansour Ghanaie, R.; Boone, I.; Shamshiri, A.R.; Karimi, A.; Amirali, A.; Marhamati, N.; Rostami, M.H.; Pashaei, N.; Janbazi, S.; Azimi, L.; Khodaei, H.; Fallah, F.; Eckmanns, T.; Jansen, A.; Baradaran, H.R.; Momeny Ourimi, M.; Maham, S.; Elikaei, A.; Alebouyeh, M. Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study. Microorganisms 2023, 11, 1672.
Abstract
A population-based seroepidemiological and molecular survey for detection of earlier and re-cent SARS-CoV-2 infection was done in children aged 14 years or less in Tehran between 19 September 2020 and 21 June 2021. Demographic data, COVID-19 symptoms and infection status were recorded and IgG antibodies and RNA of SARS-CoV-2 were detected in sera and nasopha-ryngeal swab samples, respectively. Out of 1517 participants, cardinal symptoms of COVID-19 (fever >38 oC and/or cough and/or diarrhea) were detected in 18% and serological history of SARS-CoV-2 infection and PCR positivity were confirmed in 33.2% and 10.7% of the weighted-population, respectively. SARS-CoV-2 infection was significantly higher among 10–14-year-old children. Active infection was significantly higher in symptomatic children and during autumn 2020 and spring 2021. The RT-qPCR positivity was related to contact with in-fected persons. RT-qPCR positivity was significantly higher among families with a lower socio-economic status, while no association between RT-qPCR- or seropositivity was determined with household size, underlying diseases, or gender. In conclusion, high SARS-CoV-2 infection prev-alence and seroprevalence was detected in children in Tehran in different seasons. The infection was significantly higher in older age children, and those with a positive-history of close contact with infected cases and/or lower socioeconomic status.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
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