Version 1
: Received: 22 April 2023 / Approved: 24 April 2023 / Online: 24 April 2023 (04:51:12 CEST)
How to cite:
Chetta, M.; Cammarota, A.L.; De Marco, M.; Bukvic, N.; Marzullo, L.; Rosati, A. The Continuous Adaptive Challenge Played by Arboviruses: An In Silico Approach to Define Relevant Molecular Interactions with the Host. Preprints2023, 2023040823. https://doi.org/10.20944/preprints202304.0823.v1
Chetta, M.; Cammarota, A.L.; De Marco, M.; Bukvic, N.; Marzullo, L.; Rosati, A. The Continuous Adaptive Challenge Played by Arboviruses: An In Silico Approach to Define Relevant Molecular Interactions with the Host. Preprints 2023, 2023040823. https://doi.org/10.20944/preprints202304.0823.v1
Chetta, M.; Cammarota, A.L.; De Marco, M.; Bukvic, N.; Marzullo, L.; Rosati, A. The Continuous Adaptive Challenge Played by Arboviruses: An In Silico Approach to Define Relevant Molecular Interactions with the Host. Preprints2023, 2023040823. https://doi.org/10.20944/preprints202304.0823.v1
APA Style
Chetta, M., Cammarota, A.L., De Marco, M., Bukvic, N., Marzullo, L., & Rosati, A. (2023). The Continuous Adaptive Challenge Played by Arboviruses: An <em>In Silico </em>Approach to Define Relevant Molecular Interactions with the Host. Preprints. https://doi.org/10.20944/preprints202304.0823.v1
Chicago/Turabian Style
Chetta, M., Liberato Marzullo and Alessandra Rosati. 2023 "The Continuous Adaptive Challenge Played by Arboviruses: An <em>In Silico </em>Approach to Define Relevant Molecular Interactions with the Host" Preprints. https://doi.org/10.20944/preprints202304.0823.v1
Abstract
Climate change and globalization have raised the risk of vector-borne disease (VBD) introduction and spread in various European nations in recent years. In Italy, viruses carried by tropical vectors have been shown to cause viral encephalitis, one of the symptoms of arbovirosis, a spectrum of viral disorders spread by arthropods such as mosquitoes and ticks. Arbovirosis are currently causing alarm and attention, and the World Health Organization (WHO) has released recommendations to adopt essential measures, particularly during the hot season, to restrict the spreading of the infectious agents among breeding stocks. In this scenario, rapid analysis systems are required, because they can quickly provide information on potential virus-host interactions, the evolution of the infection, and the onset of disabling clinical symptoms, or serious illnesses. Such systems include bioinformatics approaches integrated with molecular evaluation. Viruses have co-evolved different strategies to transcribe their own genetic material, by changing the host's transcriptional machinery, even in short periods of time. The introduction of genetic alterations, particularly in RNA viruses, results in a continuous adaptive fight against the host's immune system. We suggest an in silico pipeline method to unravel viral sequences that may interact with host RNA binding proteins (RBPs), which play important roles in RNA metabolism and its several related biological processes. Indeed, viral RNA sequences, able to bind host RBPs may compete with cellular RNAs, altering important metabolic processes. Our findings suggest that the proposed in silico approach, could be a useful and promising tool to investigate the complex and multiform clinical manifestations of viral encephalitis, and possibly identify altered metabolic pathways as targets of pharmacological treatments and innovative therapeutic protocols.
Public Health and Healthcare, Health Policy and Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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