Version 1
: Received: 19 April 2023 / Approved: 20 April 2023 / Online: 20 April 2023 (07:34:29 CEST)
How to cite:
Benites, E.M.; Carrillo, E.; Heras, M. Plaque Psoriasis: Effectiveness and Therapeutic Safety Using a Topical Cream of Natural Origin Quasi–experimental Clinical Trial. Preprints2023, 2023040617. https://doi.org/10.20944/preprints202304.0617.v1
Benites, E.M.; Carrillo, E.; Heras, M. Plaque Psoriasis: Effectiveness and Therapeutic Safety Using a Topical Cream of Natural Origin Quasi–experimental Clinical Trial. Preprints 2023, 2023040617. https://doi.org/10.20944/preprints202304.0617.v1
Benites, E.M.; Carrillo, E.; Heras, M. Plaque Psoriasis: Effectiveness and Therapeutic Safety Using a Topical Cream of Natural Origin Quasi–experimental Clinical Trial. Preprints2023, 2023040617. https://doi.org/10.20944/preprints202304.0617.v1
APA Style
Benites, E.M., Carrillo, E., & Heras, M. (2023). Plaque Psoriasis: Effectiveness and Therapeutic Safety Using a Topical Cream of Natural Origin Quasi–experimental Clinical Trial. Preprints. https://doi.org/10.20944/preprints202304.0617.v1
Chicago/Turabian Style
Benites, E.M., Esmeralda Carrillo and Martha Heras. 2023 "Plaque Psoriasis: Effectiveness and Therapeutic Safety Using a Topical Cream of Natural Origin Quasi–experimental Clinical Trial" Preprints. https://doi.org/10.20944/preprints202304.0617.v1
Abstract
Introduction: Psoriasis is an inflammatory skin disease. The objective was to elaborate a cream with natural products and salicylic acid. Hypothesis: ¿Will the topical cream made from natural products reduce the characteristic clinical signs of psoriasis? Methodology: Quasi-experimental clinical trial, in 100 healthy volunteer subjects, five formulations of the new product were prepared and applied to each 20 healthy subjects. The universe was 270 patients with different type of dermatology disease, 120 volunteer patients were selected with Psoriasis, of which he creams was applied to 60 volunteer patients with mild and moderate psoriasis were no randomly administered the full formulation of the new product at TMC Hospital. The database for this study is in the Figshare and Dryad repository. Outcome: In healthy subjects showed that 99% had no side effects. In psoriasis patient mild and moderate psoriasis at TMC Hospital was evaluated the results before and after treatment with the new formulation, Using T Student for paired tests, in the clinical variables, as well as the PASI index and the SBA, the alternative hypothesis was proved, the new formula is effective in the control post treatment of psoriasis (p=0.000). Discussion: The new formulation showed greater efficacy after 10 days treatment. This cream is recommended as an alternative and complementary therapy for psoriasis, since it did not show secondary reactions in healthy subjects, so its effectiveness was demonstrated in this study. A new population study is recommended by regions in Ecuador: coast, highlands, Amazon and Galapagos Island, to evaluate the response to treatment.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
