Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Cross sectional Observational Study of Safety and Protective Effects of Maternal Influenza Vaccination on Pregnancy and Birth Outcomes in pregnant women from Pune, India

Hanif Shaikh
* ,
Pranesha Koli
,
Anil Pardeshi
ORCID logo ,
Vaishali Undale
ORCID logo ,
Mahesh Asalkar
,
Sushant Sahatrabuddhe
,
Anand Kawade
,
Chandrashekhar Upasani
ORCID logo
Version 1 : Received: 30 March 2023 / Approved: 3 April 2023 / Online: 3 April 2023 (11:00:36 CEST)

A peer-reviewed article of this Preprint also exists.

Shaikh, H.; Koli, P.; Undale, V.; Pardeshi, A.; Asalkar, M.; Sahastrabuddhe, S.; Kawade, A.; Upasani, C. Safety and Protective Effects of Influenza Vaccination in Pregnant Women on Pregnancy and Birth Outcomes in Pune, India: A Cross-Sectional Study. Vaccines 2023, 11, 1034. Shaikh, H.; Koli, P.; Undale, V.; Pardeshi, A.; Asalkar, M.; Sahastrabuddhe, S.; Kawade, A.; Upasani, C. Safety and Protective Effects of Influenza Vaccination in Pregnant Women on Pregnancy and Birth Outcomes in Pune, India: A Cross-Sectional Study. Vaccines 2023, 11, 1034.

Abstract

Background: Maternal influenza vaccination provides effective protection against influenza in-fections in pregnant women and new-borns. In India, the influenza vaccine has not yet been of-fered through immunization programs, owing to the lack of sufficient safety data for Indian pregnant women. Methods: This cross-sectional observational study enrolled 558 women ad-mitted to the obstetrics ward of a civic hospital in Pune. Study-related information was obtained from the participants through interviews using structured questionnaires and hospital records. Univariate and multivariate analysis were used and chi-square with unadjusted and adjusted odds ratio were estimated to account for vaccine exposure and the temporal nature of each out-come, respectively. Results: The protective effect of maternal influenza vaccination against delivering very low birth weight infants was observed. (aOR 2.29, 95% CI 1.03 to 5.58, p=0.03). No association was observed between maternal influenza vaccination for spontaneous abortion (OR 1.42, 95%CI 0.75, 2.68), chorioamnionitis (OR 0.60, 95% CI, 0.1, 3.63), gestational hypertension (OR 1.73, 95% CI 0.72, 4.16) and preterm birth (OR 1.64, 95% CI 0.91, 2.97). Interpretation: These results show that the in-fluenza vaccine administered during pregnancy is safe and has a lower risk of negative birth outcomes.

Keywords

Maternal immunization; influenza vaccination; pregnant women; pregnancy outcome

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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