Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Cross sectional Observational Study of Safety and Protective Effects of Maternal Influenza Vaccination on Pregnancy and Birth Outcomes in pregnant women from Pune, India

Hanif Shaikh
* ,
Pranesha Koli
,
Anil Pardeshi
ORCID logo ,
Vaishali Undale
ORCID logo ,
Mahesh Asalkar
,
Sushant Sahatrabuddhe
,
Anand Kawade
,
Chandrashekhar Upasani
ORCID logo
Version 1 : Received: 30 March 2023 / Approved: 3 April 2023 / Online: 3 April 2023 (11:00:36 CEST)

A peer-reviewed article of this Preprint also exists.

Shaikh, H.; Koli, P.; Undale, V.; Pardeshi, A.; Asalkar, M.; Sahastrabuddhe, S.; Kawade, A.; Upasani, C. Safety and Protective Effects of Influenza Vaccination in Pregnant Women on Pregnancy and Birth Outcomes in Pune, India: A Cross-Sectional Study. Vaccines 2023, 11, 1034. Shaikh, H.; Koli, P.; Undale, V.; Pardeshi, A.; Asalkar, M.; Sahastrabuddhe, S.; Kawade, A.; Upasani, C. Safety and Protective Effects of Influenza Vaccination in Pregnant Women on Pregnancy and Birth Outcomes in Pune, India: A Cross-Sectional Study. Vaccines 2023, 11, 1034.

Abstract

Background: Maternal influenza vaccination provides effective protection against influenza in-fections in pregnant women and new-borns. In India, the influenza vaccine has not yet been of-fered through immunization programs, owing to the lack of sufficient safety data for Indian pregnant women. Methods: This cross-sectional observational study enrolled 558 women ad-mitted to the obstetrics ward of a civic hospital in Pune. Study-related information was obtained from the participants through interviews using structured questionnaires and hospital records. Univariate and multivariate analysis were used and chi-square with unadjusted and adjusted odds ratio were estimated to account for vaccine exposure and the temporal nature of each out-come, respectively. Results: The protective effect of maternal influenza vaccination against delivering very low birth weight infants was observed. (aOR 2.29, 95% CI 1.03 to 5.58, p=0.03). No association was observed between maternal influenza vaccination for spontaneous abortion (OR 1.42, 95%CI 0.75, 2.68), chorioamnionitis (OR 0.60, 95% CI, 0.1, 3.63), gestational hypertension (OR 1.73, 95% CI 0.72, 4.16) and preterm birth (OR 1.64, 95% CI 0.91, 2.97). Interpretation: These results show that the in-fluenza vaccine administered during pregnancy is safe and has a lower risk of negative birth outcomes.

Keywords

Maternal immunization; influenza vaccination; pregnant women; pregnancy outcome

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.