Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Emergency Endoscopic Haemostasis for Gastrointestinal Bleeding using A Self-Assembling Peptide: A Case Series

Takashi Murakami
* ORCID logo ,
Eiji Kamba
,
Keiichi Haga
,
Yoichi Akazawa
,
Hiroya Ueyama
ORCID logo ,
Tomoyoshi Shibuya
ORCID logo ,
Mariko Hojo
ORCID logo ,
Akihito Nagahara
ORCID logo
Version 1 : Received: 26 March 2023 / Approved: 27 March 2023 / Online: 27 March 2023 (10:42:18 CEST)

How to cite: Murakami, T.; Kamba, E.; Haga, K.; Akazawa, Y.; Ueyama, H.; Shibuya, T.; Hojo, M.; Nagahara, A. Emergency Endoscopic Haemostasis for Gastrointestinal Bleeding using A Self-Assembling Peptide: A Case Series. Preprints 2023, 2023030459. https://doi.org/10.20944/preprints202303.0459.v1 Murakami, T.; Kamba, E.; Haga, K.; Akazawa, Y.; Ueyama, H.; Shibuya, T.; Hojo, M.; Nagahara, A. Emergency Endoscopic Haemostasis for Gastrointestinal Bleeding using A Self-Assembling Peptide: A Case Series. Preprints 2023, 2023030459. https://doi.org/10.20944/preprints202303.0459.v1

Abstract

Background and Objectives: A novel synthetic self-assembling peptide, PuraStat, has been introduced as a hemostatic agent. This case series aimed to evaluate the clinical efficacy of PuraStat for gastrointestinal bleeding during emergency endoscopy. Cases: Twenty-five patients with gastrointestinal bleeding who had undergone emergency endoscopy with PuraStat between August 2021 and December 2022 were retrospectively examined. Six patients were receiving antithrombotic agent, and ten patients with refractory gastrointestinal bleeding had undergone at least one endoscopic hemostatic procedure. The breakdown of bleeding was gastroduodenal ulcer/erosion in 12 cases, bleeding after gastroduodenal or colorectal endoscopic resection in 4 cases, rectal ulcer in 2 cases, postoperative anastomotic ulcer in 2 cases, and gastric cancer, diffuse antral vascular ectasia, small intestinal ulcer, colonic diverticular bleeding, and radiation proctitis in each case. The method of hemostasis was only PuraStat application in six cases, and hemostasis in combination with high-frequency hemostatic forceps, hemostatic clip, argon plasma coagulation, and hemostatic agents (i.e. thrombin) in the remaining cases. Rebleeding was observed in three cases. Hemostatic efficiency was observed in 23 cases (92%). Conclusions: PuraStat has the expected hemostatic effect on gastrointestinal bleeding during emergency endoscopy. The use of PuraStat should be considered in emergency endoscopic hemostasis of gastrointestinal bleeding.

Keywords

endoscopic hemostasis; emergency endoscopy; gastrointestinal bleeding; self-assembling peptide

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.