Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia

Version 1 : Received: 21 March 2023 / Approved: 22 March 2023 / Online: 22 March 2023 (06:36:20 CET)

A peer-reviewed article of this Preprint also exists.

Uchino, T.; Okubo, R.; Takubo, Y.; Aoki, A.; Wada, I.; Hashimoto, N.; Ikezawa, S.; Nemoto, T. Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia Spectrum Disorders. J. Pers. Med. 2023, 13, 683. Uchino, T.; Okubo, R.; Takubo, Y.; Aoki, A.; Wada, I.; Hashimoto, N.; Ikezawa, S.; Nemoto, T. Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia Spectrum Disorders. J. Pers. Med. 2023, 13, 683.

Abstract

Background: In schizophrenia (SZ), social cognition mediates the relationship between neurocognition and social functioning. Although people with major depressive disorder (MDD) also exhibit cognitive impairments, which are often prolonged, little is known about the role of social cognition in MDD. Methods: Using data obtained through an internet survey, 210 patients with SZ or MDD were selected using propensity score matching based on their demographic information and illness duration. Social cognition, neurocognition, and social functioning were evaluated using the Self-Assessment of Social Cognition Impairments, Perceived Deficits Questionnaire, and Social Functioning Scale, respectively. The mediation effects of social cognition on the relationship between neurocognition and social functioning were examined in each disease group. Invariances of the mediation model across the two groups were then analyzed. Results: The SZ and MDD groups had mean ages of 44.49 and 45.35 years, contained 42.0% and 42.8% women, and had mean illness durations of 10.76 and 10.45 years, respectively. In both groups, social cognition had significant mediation effects. Configural, measurement, and structural invariances across the groups were established. Conclusion: The role of social cognition in patients with chronic depression was similar to that in schizophrenia. Social cognition could be a common endophenotype for various psychiatric disorders.

Keywords

ACSo; cognitive function; depression; PDQ; psychosis; real-world functioning; schizophrenia; SFS; social functioning

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

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