Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Plasma Galectin-4 Levels are Increased after Stroke in Mice and Humans

Joao Vieira
§ ,
Amra Jujic
§ ORCID logo ,
Hana Matuskova
§ ,
Peter M. Nilsson
ORCID logo ,
Ulf Lindblad
,
Michael Hecht Olsen
,
João M.N. Duarte
§ ORCID logo ,
Anja Meissner
§ ORCID logo ,
Martin Magnusson
*,§ ORCID logo
§
Denotes equal author contribution
Version 1 : Received: 20 March 2023 / Approved: 21 March 2023 / Online: 21 March 2023 (07:56:47 CET)

A peer-reviewed article of this Preprint also exists.

Jujic, A.; Vieira, J.P.P.; Matuskova, H.; Nilsson, P.M.; Lindblad, U.; Olsen, M.H.; Duarte, J.M.N.; Meissner, A.; Magnusson, M. Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans. Int. J. Mol. Sci. 2023, 24, 10064. Jujic, A.; Vieira, J.P.P.; Matuskova, H.; Nilsson, P.M.; Lindblad, U.; Olsen, M.H.; Duarte, J.M.N.; Meissner, A.; Magnusson, M. Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans. Int. J. Mol. Sci. 2023, 24, 10064.

Abstract

Background Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with increased risk of coronary artery disease, but data regarding possible associations with stroke are lacking. Methods We tested Gal-4 association with prevalent stroke in a population-based cohort, and whether Gal-4 increases after ischemic stroke in mice fed a high-fat diet (HFD). Results Gal-4 was higher in subjects with compared to without prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01-2.30; p=0.048) adjusted for age, sex and covariates of cardiometabolic health. Plasma Gal-4 increased after stroke in both controls and HFD-fed mice, but HFD exposure was devoid of impact in Gal-4 levels. Conclusions This study demonstrates higher plasma Gal-4 levels in both a stroke mouse model and individuals with prevalent stroke.

Keywords

ischemia; cardiovascular disease; diabetes; obesity; galectins

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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