Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Plasma Galectin-4 Levels are Increased after Stroke in Mice and Humans

Joao Vieira
§ ,
Amra Jujic
§ ORCID logo ,
Hana Matuskova
§ ,
Peter M. Nilsson
ORCID logo ,
Ulf Lindblad
,
Michael Hecht Olsen
,
João M.N. Duarte
§ ORCID logo ,
Anja Meissner
§ ORCID logo ,
Martin Magnusson
*,§ ORCID logo
§
Denotes equal author contribution
Version 1 : Received: 20 March 2023 / Approved: 21 March 2023 / Online: 21 March 2023 (07:56:47 CET)

A peer-reviewed article of this Preprint also exists.

Jujic, A.; Vieira, J.P.P.; Matuskova, H.; Nilsson, P.M.; Lindblad, U.; Olsen, M.H.; Duarte, J.M.N.; Meissner, A.; Magnusson, M. Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans. Int. J. Mol. Sci. 2023, 24, 10064. Jujic, A.; Vieira, J.P.P.; Matuskova, H.; Nilsson, P.M.; Lindblad, U.; Olsen, M.H.; Duarte, J.M.N.; Meissner, A.; Magnusson, M. Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans. Int. J. Mol. Sci. 2023, 24, 10064.

Abstract

Background Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with increased risk of coronary artery disease, but data regarding possible associations with stroke are lacking. Methods We tested Gal-4 association with prevalent stroke in a population-based cohort, and whether Gal-4 increases after ischemic stroke in mice fed a high-fat diet (HFD). Results Gal-4 was higher in subjects with compared to without prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01-2.30; p=0.048) adjusted for age, sex and covariates of cardiometabolic health. Plasma Gal-4 increased after stroke in both controls and HFD-fed mice, but HFD exposure was devoid of impact in Gal-4 levels. Conclusions This study demonstrates higher plasma Gal-4 levels in both a stroke mouse model and individuals with prevalent stroke.

Keywords

ischemia; cardiovascular disease; diabetes; obesity; galectins

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.