Version 1
: Received: 20 March 2023 / Approved: 21 March 2023 / Online: 21 March 2023 (01:36:35 CET)
How to cite:
Hur, K.Y. Inconsistent Outcomes of Metabolic Surgery for Nonobese Patients with Type 2 Diabetes. Preprints2023, 2023030361. https://doi.org/10.20944/preprints202303.0361.v1
Hur, K.Y. Inconsistent Outcomes of Metabolic Surgery for Nonobese Patients with Type 2 Diabetes. Preprints 2023, 2023030361. https://doi.org/10.20944/preprints202303.0361.v1
Hur, K.Y. Inconsistent Outcomes of Metabolic Surgery for Nonobese Patients with Type 2 Diabetes. Preprints2023, 2023030361. https://doi.org/10.20944/preprints202303.0361.v1
APA Style
Hur, K.Y. (2023). Inconsistent Outcomes of Metabolic Surgery for Nonobese Patients with Type 2 Diabetes. Preprints. https://doi.org/10.20944/preprints202303.0361.v1
Chicago/Turabian Style
Hur, K.Y. 2023 "Inconsistent Outcomes of Metabolic Surgery for Nonobese Patients with Type 2 Diabetes" Preprints. https://doi.org/10.20944/preprints202303.0361.v1
Abstract
Metabolic surgery can promote integrated physiologic improvement to ameliorate metabolic illness, particularly type 2 diabetes. Nevertheless, the therapeutic scope has been limited by unexpectedly inconsistent surgical outcomes. Therefore, the purpose of this study is to overcome the obstacles by determining the core mechanism of conflicting results. The surgical anatomy, clinical course, and outcomes of various metabolic surgeries, including modified types of duodenal-jejunal bypass procedures, were compared to comprehend specific surgical patterns from distinctive perspectives. Patients in exclusively nonobese groups are subjected to avoid compounding by weight fluctuations. During intestinal anastomosis, the epithelial identity of the succeeding intestine is replaced by that of the proximal epithelium through altered crosstalk between the epithelium and opposing mesenchymal cells. The rapid turnover rate and compensatory proliferation of the succeeding intestine accelerate the propagation of the replaced epithelium. Propagation of replaced epithelium could provoke inconsistent outcomes of metabolic surgery. The major determinants of the conflicting results of metabolic surgery are inadequate duodenal exclusion and inappropriate length of the biliopancreatic limbs. The replaced enteroendocrine cells during regeneration provoke inconsistent outcomes of metabolic surgery. The critical factors are the type and density of enteroendocrine cells distributed at the terminal end of the preceding proximal intestine.
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
