Version 1
: Received: 18 March 2023 / Approved: 20 March 2023 / Online: 20 March 2023 (07:46:35 CET)
How to cite:
Fusco, D.; Liu, S.; Theberge, M.; Reynaud, P.; Drouin, A. Admission Systolic Blood Pressure and Obesity Correlate with Severe Acute COVID-19 in the Population of New Orleans, LA. Preprints2023, 2023030351. https://doi.org/10.20944/preprints202303.0351.v1
Fusco, D.; Liu, S.; Theberge, M.; Reynaud, P.; Drouin, A. Admission Systolic Blood Pressure and Obesity Correlate with Severe Acute COVID-19 in the Population of New Orleans, LA. Preprints 2023, 2023030351. https://doi.org/10.20944/preprints202303.0351.v1
Fusco, D.; Liu, S.; Theberge, M.; Reynaud, P.; Drouin, A. Admission Systolic Blood Pressure and Obesity Correlate with Severe Acute COVID-19 in the Population of New Orleans, LA. Preprints2023, 2023030351. https://doi.org/10.20944/preprints202303.0351.v1
APA Style
Fusco, D., Liu, S., Theberge, M., Reynaud, P., & Drouin, A. (2023). Admission Systolic Blood Pressure and Obesity Correlate with Severe Acute COVID-19 in the Population of New Orleans, LA. Preprints. https://doi.org/10.20944/preprints202303.0351.v1
Chicago/Turabian Style
Fusco, D., Peter Reynaud and Arnaud Drouin. 2023 "Admission Systolic Blood Pressure and Obesity Correlate with Severe Acute COVID-19 in the Population of New Orleans, LA" Preprints. https://doi.org/10.20944/preprints202303.0351.v1
Abstract
In New Orleans, Louisiana the population’s poor baseline health led to its establishment as an early epicenter for severe acute COVID-19. Antici-pating future outbreaks of COVID-19 and other respiratory viruses, we need to identify correlates of outcome, from real clinical experience. 89 patients were recruited into the ClinSeqSer acute COVID-19 longitudinal observational study, from the beginning of the outbreak in March to July 2020. Patients admitted for acute COVID-19 were enrolled in person. The cohort is unique as it is 68% Black, 53% female, of average age of early 60s, and prevalence of obesity and hypertension respectively of 55% and 83%. The outcomes are: 53% severe (20% fatal, 33% non-fatal) and 47% non-severe, with severe defined as death or requiring mechanical ventila-tion or high flow oxygen. Obesity and admit systolic blood pressure (SBP) >140mmHg are each associated with severe outcome and, despite respective sensitivity of 71% and 76%, specificity ~66% for both, and ac-curacy of 60% and 70% by ROC analysis, would likely provide useful predictors of outcome in critically stressed health care systems. We discuss pathophysiologic hypotheses to explain why high admit SBP is observed only in half of patients with pre-COVID hypertension and is associated with severe outcome.
Keywords
COVID-19; SARS CoV-2; hypertension; obesity; clinical predictor of outcomes; clinical triage; ClinSeqSer acute COVID-19 observational study
Subject
Medicine and Pharmacology, Urology and Nephrology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
