Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of the Gut Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence

Version 1 : Received: 28 February 2023 / Approved: 9 March 2023 / Online: 9 March 2023 (03:12:39 CET)

A peer-reviewed article of this Preprint also exists.

Bragazzi, M.C.; Venere, R.; Vignone, A.; Alvaro, D.; Cardinale, V. Role of the Gut–Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence. Int. J. Mol. Sci. 2023, 24, 6660. Bragazzi, M.C.; Venere, R.; Vignone, A.; Alvaro, D.; Cardinale, V. Role of the Gut–Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence. Int. J. Mol. Sci. 2023, 24, 6660.

Abstract

The “Gut-Liver Axis” refers to physiological bidirectional interplay between the gut and its microbiota and the liver which, in health, occurs thanks to a condition of immune tolerance. In recent years, several studies have shown that, in case of modifications of gut bacterial homeostasis or impairment of intestinal barrier functions, cholangiocytes, which are the epithelial cells lining the bile ducts, activate innate immune responses against gut-derived microorganisms or bacterial products that reach the liver via enterohepatic circulation. Intestinal dysbiosis or impaired intestinal barrier functions expose cholangiocytes to an increasing amount of microorganisms and may exacerbate inflammatory responses thus leading to fibrotic remodeling of the organ. The present review focuses on the role of the gut liver axis in the pathogenesis of cholangiopathies.

Keywords

mucosal barrier; cholangiocarcinoma; gut-liver-axis; primay biliary cholangitis; primay sclerosing cholangitis

Subject

Medicine and Pharmacology, Dermatology

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