Possible Role of Inflammasomes in the Pathogenesis of Periodontal Diseases

Nada Hashim; Rasha Babiker; Riham Mohammed; Mohammed Mustahsen Rehman; Bakri Gismalla

doi:10.20944/preprints202301.0416.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 20 January 2023 / Approved: 23 January 2023 / Online: 23 January 2023 (15:07:31 CET)

Dr. Jurg Tschopp created the word "inflammasome" in 2002. Inflammasome activation and its function in disease processes have been the subject of significant investigation over the last 15 years. Four important inflammasomes have been identified: NLRP1, NLRP3, NLRC4, and AIM2. When these inflammasomes are activated, they process and secrete inflammatory cytokines such as IL-1b and IL-18, as well as cause pyroptosis, an inflammatory form of cell death. In this review, we will look at how these inflammasomes have been connected to Periodontitis pathogenesis.

Inflammasome; NLRP3; periodontal disease; periodontal pathogen; IL-1β

Medicine and Pharmacology, Dentistry and Oral Surgery

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Possible Role of Inflammasomes in the Pathogenesis of Periodontal Diseases

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