Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Vaccination and Younger Age Are Associated with Recurrent Laboratory-Confirmed Symptomatic SARS-Cov-2 Infections

Version 1 : Received: 25 December 2022 / Approved: 26 December 2022 / Online: 26 December 2022 (03:53:55 CET)

How to cite: Ríos-Silva, M.; Trujillo, X.; Huerta, M.; Guzmán-Esquivel, J.; Benites-Godínez, V.; Lugo-Radillo, A.; Bricio-Barrios, J.A.; Ríos-Bracamontes, E.F.; Ortega-Macías, V.M.; Ruiz-Montes de Oca, V.; Mendoza-Cano, O.; Murillo-Zamora, E. Vaccination and Younger Age Are Associated with Recurrent Laboratory-Confirmed Symptomatic SARS-Cov-2 Infections. Preprints 2022, 2022120469. https://doi.org/10.20944/preprints202212.0469.v1 Ríos-Silva, M.; Trujillo, X.; Huerta, M.; Guzmán-Esquivel, J.; Benites-Godínez, V.; Lugo-Radillo, A.; Bricio-Barrios, J.A.; Ríos-Bracamontes, E.F.; Ortega-Macías, V.M.; Ruiz-Montes de Oca, V.; Mendoza-Cano, O.; Murillo-Zamora, E. Vaccination and Younger Age Are Associated with Recurrent Laboratory-Confirmed Symptomatic SARS-Cov-2 Infections. Preprints 2022, 2022120469. https://doi.org/10.20944/preprints202212.0469.v1

Abstract

Background: Repeated SARS-CoV-2 infections are plausible and related published data are scarce. We aimed to identify factors associated with the risk of recurrent (three episodes) laboratory-confirmed symptomatic SARS-CoV-2 infections. Methods: A retrospective cohort study was conducted and 1,700 healthcare workers were enrolled. We used risk ratios (RR) and 95% confidence intervals (CI) to evaluate factors associated with symptomatic SARS-CoV-2 infections. Results: We identified 14 participants with recurrent illness episodes. Therefore, the incidence rate was 8.5 per 10,000 person-months. In multiple model, vaccinated adults (vs. unvaccinated, RR = 1.05 [1.03 - 1.06]) and those with a severe first illness episode (vs mild disease, RR = 1.05 [1.01 - 1.10]) were at increased risk for repeated symptomatic SARS-CoV-2 reinfections. Increasing age showed a protective effect (per each additional year of age: RR = 0.98 [0.97 - 0.99]). Conclusions: Our results suggest that recurrent SARS-CoV-2 infections are rare events in adults and they seem to be determined, partially, by vaccination status and age.

Keywords

COVID-19; SARS-CoV-2; Reinfection

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

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