Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges

Version 1 : Received: 3 December 2022 / Approved: 5 December 2022 / Online: 5 December 2022 (15:23:19 CET)

A peer-reviewed article of this Preprint also exists.

Nicholson, T.A.; Sagmeister, M.; Wijesinghe, S.N.; Farah, H.; Hardy, R.S.; Jones, S.W. Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges. Pharmaceutics 2023, 15, 237. Nicholson, T.A.; Sagmeister, M.; Wijesinghe, S.N.; Farah, H.; Hardy, R.S.; Jones, S.W. Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges. Pharmaceutics 2023, 15, 237.

Abstract

Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. Collectively, these conditions involve multiple tissues, including skeletal muscle, bone, articular cartilage and the synovium within the joint lining. In this review, we discuss the potential for oligonucleotide therapies to combat the unmet clinical need in musculoskeletal disorders by evaluating the successes of oligonucleotides to modify candidate pathological gene targets and cellular processes in relevant tissues and cells of the musculoskeletal system. Further, we discuss the challenges that remain for the clinical development of oligonucleotides therapies for musculoskeletal disorders and evaluate some of the current approaches to overcome these.

Keywords

Skeletal muscle; sarcopenia; osteoarthritis; osteoporosis; rheumatoid arthritis; oligonucleotides; cartilage; bone; synovium

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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