Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Neck Circumference in Combination with Biochemical Variables as a Surrogate Marker of NAFLD: The FLiO Study

Mariana Elorz
ORCID logo ,
Alberto Benito
,
Berta Araceli Marin
,
Nuria Perez del Campo
ORCID logo ,
Jose Ignacio Herrero
,
Ignacio Monreal
,
Josep Tur
,
J. Alfredo Martínez
,
María Ángeles Zulet
ORCID logo ,
Itziar Abete
* ORCID logo
Version 1 : Received: 28 October 2022 / Approved: 1 November 2022 / Online: 1 November 2022 (10:04:57 CET)

A peer-reviewed article of this Preprint also exists.

Elorz, M.; Benito-Boilos, A.; Marin, B.A.; Pérez Díaz del Campo, N.; Herrero, J.I.; Monreal, J.I.; Tur, J.A.; Martínez, J.A.; Zulet, M.A.; Abete, I. Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study. Nutrients 2022, 14, 5160. Elorz, M.; Benito-Boilos, A.; Marin, B.A.; Pérez Díaz del Campo, N.; Herrero, J.I.; Monreal, J.I.; Tur, J.A.; Martínez, J.A.; Zulet, M.A.; Abete, I. Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study. Nutrients 2022, 14, 5160.

Abstract

Neck circumference (NC), neck circumference to height ratio (NHtR) and neck circumference to weight ratio (NWtR) appear to be good candidates for the non-invasive management of non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the ability of routine variables to assess and manage NAFLD in participants with obesity and NAFLD included in a 2-year nutritional intervention program. Anthropometric measurements, biochemical variables and imaging techniques were performed at different study time-points (baseline, 6, 12 and 24 months). The nutritional intervention significantly improved all anthropometric measurements as well as the glucose profile and the hepatic enzymes. NC and neck ratios combined with ALT levels and HOMA-IR showed good prediction ability for the hepatic fat content and hepatic steatosis at all the study time-points in a ROC analysis. The prediction ability of the combination panels improved when the weight loss variable was also considered. NC and neck ratios are easy anthropometric measurements that in combination with routine biochemical variables (ALT and HOMA-IR) showed good prediction ability of NAFLD. More research studies are necessary to validate the utility of these simple and easy variables as surrogate markers of NAFLD since their application could improve the prevention and management of this prevalent disease.

Keywords

Anthropometric measurements; fatty liver disease; nutritional intervention; imaging techniques; long-term follow-up; neck-to-height ratio; non-invasive diagnostic methods; neck-to-weight ratio; FLIO study; steatosis markers.

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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