Version 1
: Received: 6 September 2022 / Approved: 26 September 2022 / Online: 26 September 2022 (15:01:58 CEST)
How to cite:
Clark, P.; Wordsworth, J.; green, D.; Fielder, E. The Hypothetical Utilisation of Entomopoxvirus to Achieve Rejuvenation through Cyclic Expression of Yamanaka Factors. Preprints2022, 2022090401. https://doi.org/10.20944/preprints202209.0401.v1
Clark, P.; Wordsworth, J.; green, D.; Fielder, E. The Hypothetical Utilisation of Entomopoxvirus to Achieve Rejuvenation through Cyclic Expression of Yamanaka Factors. Preprints 2022, 2022090401. https://doi.org/10.20944/preprints202209.0401.v1
Clark, P.; Wordsworth, J.; green, D.; Fielder, E. The Hypothetical Utilisation of Entomopoxvirus to Achieve Rejuvenation through Cyclic Expression of Yamanaka Factors. Preprints2022, 2022090401. https://doi.org/10.20944/preprints202209.0401.v1
APA Style
Clark, P., Wordsworth, J., green, D., & Fielder, E. (2022). The Hypothetical Utilisation of Entomopoxvirus to Achieve Rejuvenation through Cyclic Expression of Yamanaka Factors. Preprints. https://doi.org/10.20944/preprints202209.0401.v1
Chicago/Turabian Style
Clark, P., daniel green and Edward Fielder. 2022 "The Hypothetical Utilisation of Entomopoxvirus to Achieve Rejuvenation through Cyclic Expression of Yamanaka Factors" Preprints. https://doi.org/10.20944/preprints202209.0401.v1
Abstract
Epigenetic reprogramming using cyclic expression of Yamanaka factors has been demonstrated to rejuvenate on a systemic level in animal models with no obvious deleterious effects. Here we discuss a strategy for cyclic and systemic expression of Yamanaka factors in wild-type animals amenable for adaptation as a human therapy. This is based on the use of the little- known Amsacta moorei Entomopoxvirus vector in combination with microbubble mediated focused ultrasound-driven blood vessel permeabilization to facilitate the system-wide distribution of the virus.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
