Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Inferring Bona Fide Differentially Expressed Genes and Their Variants Associated With Vitamin K Deficiency Using Systems Genetics Approach

Shalini Rajagopal
,
Akanksha Sharma
,
Anita Simlot
,
Praveen Mathur
,
Sumita Mehta
,
Sudhir Mehta
,
Jalaja Naravula
,
Krishna Mohan Medicherla
ORCID logo ,
Anil Kumar
,
Uma Kanga
ORCID logo ,
Renuka Suravajhala
,
Ramji Bhandari
,
Bipin Nair
,
Kavi Kishor PB
,
Prashanth Suravajhala
* ORCID logo
Version 1 : Received: 21 September 2022 / Approved: 23 September 2022 / Online: 23 September 2022 (09:13:29 CEST)

A peer-reviewed article of this Preprint also exists.

Rajagopal, S.; Sharma, A.; Simlot, A.; Mathur, P.; Mehta, S.; Mehta, S.; Naravula, J.; Medicherla, K.M.; Kumar, A.; Kanga, U.; Suravajhala, R.; Bhandari, R.K.; Nair, B.G.; Kishor, P.B.K.; Suravajhala, P. Inferring bona fide Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a Systems Genetics Approach. Genes 2022, 13, 2078. Rajagopal, S.; Sharma, A.; Simlot, A.; Mathur, P.; Mehta, S.; Mehta, S.; Naravula, J.; Medicherla, K.M.; Kumar, A.; Kanga, U.; Suravajhala, R.; Bhandari, R.K.; Nair, B.G.; Kishor, P.B.K.; Suravajhala, P. Inferring bona fide Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a Systems Genetics Approach. Genes 2022, 13, 2078.

Abstract

Systems genetics is key for integrating a large number of variants associated with diseases. Vitamin K (VK) is one of the scarcely studied conditions in lieu of ascertaining either the differentially expressed genes (DEGs) or variants in an individual subpopulation of diseased phenotypes associated with VK, viz. myocardial infarction, renal failure, prostate cancer, thrombosis, thrombocytopenia, coagulation related diseases to name a few. In this work, we have screened characteristic DEGs common to three VK-related diseases, viz. myocardial infarction, renal failure and prostate cancer and asked whether or not any DEGs in addition to pathogenic variants are common to these conditions. We attempt to bridge the gap in finding characteristic biomarkers and discuss the role of long noncoding RNAs (lncRNAs) in the biogenesis of VK deficiencies.

Keywords

RNA-Seq; Vitamin K; Comorbidities; Differential Expressed Genes; Variant analysis

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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