Review
Version 1
Preserved in Portico This version is not peer-reviewed
An Overview of the Infectious Cycle of Bunyaviruses
Version 1
: Received: 3 September 2022 / Approved: 5 September 2022 / Online: 5 September 2022 (07:49:30 CEST)
A peer-reviewed article of this Preprint also exists.
Boshra, H. An Overview of the Infectious Cycle of Bunyaviruses. Viruses 2022, 14, 2139. Boshra, H. An Overview of the Infectious Cycle of Bunyaviruses. Viruses 2022, 14, 2139.
Abstract
Bunyaviruses represent the largest group of RNA viruses, and are the causative agent of a variety of febrile and hemorrhagic illnesses. Originally characterized as a single serotype in Africa, the number of described bunyaviruses now exceeds over 500, with its presence detected around the world. These predominantly tri-segmented, single-stranded RNA viruses are transmitted primarily through arthropod and rodent vectors, and can infect a wide variety of animal and plants. Although encoding for a small number of proteins, these viruses can inflict potentially fatal disease outcomes, and have even developed strategies to suppress the innate antiviral immune mechanisms of the infected host. This short review will attempt to provide an overall description of the order Bunyavirales, describing the mechanisms behind their infection, replication and their evasion of the host immune response. Furthermore, the historical context of these virus will be presented, starting from their original discovery almost 80 years ago, to the most recent research pertaining to viral replication and host immune response.
Keywords
bunyavirus; structure; genomics; immune response; review
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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