«Enzymatic Landscape» of the Gut Microbiome in Obese Patients

Olga Petrovna Shatova; Tatyana Vladimirovna Grigorieva; Svetlana Alexandrovna Appolonova; Valentin Vladimirovich Makarov; Sergey Mikhailovich Yudin; Sergey Aleksandrovich Roumiantsev; Andrey Mikhailovich Gaponov; Alexander Vyacheslavovich Shestopalov

doi:10.20944/preprints202208.0436.v1

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preprints.org > biology and life sciences > endocrinology and metabolism > doi: 10.20944/preprints202208.0436.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

«Enzymatic Landscape» of the Gut Microbiome in Obese Patients

Olga Petrovna Shatova

^* ,

Tatyana Vladimirovna Grigorieva

Svetlana Alexandrovna Appolonova

Valentin Vladimirovich Makarov

Sergey Mikhailovich Yudin

Sergey Aleksandrovich Roumiantsev

Andrey Mikhailovich Gaponov

Alexander Vyacheslavovich Shestopalov

Version 1 : Received: 23 August 2022 / Approved: 25 August 2022 / Online: 25 August 2022 (13:21:39 CEST)

How to cite: Shatova, O. P.; Grigorieva, T. V.; Appolonova, S. A.; Makarov, V. V.; Yudin, S. M.; Roumiantsev, S. A.; Gaponov, A. M.; Shestopalov, A. V. «Enzymatic Landscape» of the Gut Microbiome in Obese Patients. Preprints 2022, 2022080436. https://doi.org/10.20944/preprints202208.0436.v1 Shatova, O. P.; Grigorieva, T. V.; Appolonova, S. A.; Makarov, V. V.; Yudin, S. M.; Roumiantsev, S. A.; Gaponov, A. M.; Shestopalov, A. V. «Enzymatic Landscape» of the Gut Microbiome in Obese Patients. Preprints 2022, 2022080436. https://doi.org/10.20944/preprints202208.0436.v1

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MDPI and ACS Style

Shatova, O. P.; Grigorieva, T. V.; Appolonova, S. A.; Makarov, V. V.; Yudin, S. M.; Roumiantsev, S. A.; Gaponov, A. M.; Shestopalov, A. V. «Enzymatic Landscape» of the Gut Microbiome in Obese Patients. Preprints 2022, 2022080436. https://doi.org/10.20944/preprints202208.0436.v1

APA Style

Shatova, O. P., Grigorieva, T. V., Appolonova, S. A., Makarov, V. V., Yudin, S. M., Roumiantsev, S. A., Gaponov, A. M., & Shestopalov, A. V. (2022). «Enzymatic Landscape» of the Gut Microbiome in Obese Patients. Preprints. https://doi.org/10.20944/preprints202208.0436.v1

Chicago/Turabian Style

Shatova, O. P., Andrey Mikhailovich Gaponov and Alexander Vyacheslavovich Shestopalov. 2022 "«Enzymatic Landscape» of the Gut Microbiome in Obese Patients" Preprints. https://doi.org/10.20944/preprints202208.0436.v1

Abstract

Indole and indole-3-lactate are known dominant microbial tryptophan catabolites (MICT). In obesity, the fecal indole concentration corresponds to the normal one, and that of indole-3-lactate significantly decreases along with other MICT, while it increases in blood plasma. During the analysis of the «enzymatic landscape» of the intestinal microbiota we find an almost twofold increase in the correlation between the concentrations of fecal MICT and the «enzymatic landscape», with indole-3-lactate having the closest relationships with the “enzymatic landscape” of all MICT. Here, we report statistically significant correlations of indole-3-lactate and the gut microbial enzymes for fructose, amino sugars, nucleotides, polyamines metabolism, and sulfoglycolysis. We also demonstrate that indole-3-lactate producing microbiota representatives increase three-fold in obesity. The phenotype of the microbiotic population is thus represented by completely different genera and species of microorganisms in obese individuals compared to healthy donors.

Keywords

tryptophan metabolites; microbiome; obesity; enzymatic landscape

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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