«Enzymatic Landscape» of the Gut Microbiome in Obese Patients

Olga Petrovna Shatova; Tatyana Vladimirovna Grigorieva; Svetlana Alexandrovna Appolonova; Valentin Vladimirovich Makarov; Sergey Mikhailovich Yudin; Sergey Aleksandrovich Roumiantsev; Andrey Mikhailovich Gaponov; Alexander Vyacheslavovich Shestopalov

doi:10.20944/preprints202208.0436.v1

Submit preprint
How it Works
Instructions for Authors
Subject Areas
Advisory Board
screening preprints
About
Awards
Log in/Register

Instructions for Authors
Awards
About
FAQ
Submit Log in/Register

Share this article with

Create alert

Email:

Load new image

preprints.org > biology and life sciences > endocrinology and metabolism > doi: 10.20944/preprints202208.0436.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

«Enzymatic Landscape» of the Gut Microbiome in Obese Patients

Olga Petrovna Shatova

^* ,

Tatyana Vladimirovna Grigorieva

Svetlana Alexandrovna Appolonova

Valentin Vladimirovich Makarov

Sergey Mikhailovich Yudin

Sergey Aleksandrovich Roumiantsev

Andrey Mikhailovich Gaponov

Alexander Vyacheslavovich Shestopalov

Version 1 : Received: 23 August 2022 / Approved: 25 August 2022 / Online: 25 August 2022 (13:21:39 CEST)

How to cite: Shatova, O.P.; Grigorieva, T.V.; Appolonova, S.A.; Makarov, V.V.; Yudin, S.M.; Roumiantsev, S.A.; Gaponov, A.M.; Shestopalov, A.V. «Enzymatic Landscape» of the Gut Microbiome in Obese Patients. Preprints 2022, 2022080436. https://doi.org/10.20944/preprints202208.0436.v1 Shatova, O.P.; Grigorieva, T.V.; Appolonova, S.A.; Makarov, V.V.; Yudin, S.M.; Roumiantsev, S.A.; Gaponov, A.M.; Shestopalov, A.V. «Enzymatic Landscape» of the Gut Microbiome in Obese Patients. Preprints 2022, 2022080436. https://doi.org/10.20944/preprints202208.0436.v1

Cite

Export citation file: Bib TeX | RIS

MDPI and ACS Style

Shatova, O.P.; Grigorieva, T.V.; Appolonova, S.A.; Makarov, V.V.; Yudin, S.M.; Roumiantsev, S.A.; Gaponov, A.M.; Shestopalov, A.V. «Enzymatic Landscape» of the Gut Microbiome in Obese Patients. Preprints 2022, 2022080436. https://doi.org/10.20944/preprints202208.0436.v1

APA Style

Shatova, O.P., Grigorieva, T.V., Appolonova, S.A., Makarov, V.V., Yudin, S.M., Roumiantsev, S.A., Gaponov, A.M., & Shestopalov, A.V. (2022). «Enzymatic Landscape» of the Gut Microbiome in Obese Patients. Preprints. https://doi.org/10.20944/preprints202208.0436.v1

Chicago/Turabian Style

Shatova, O.P., Andrey Mikhailovich Gaponov and Alexander Vyacheslavovich Shestopalov. 2022 "«Enzymatic Landscape» of the Gut Microbiome in Obese Patients" Preprints. https://doi.org/10.20944/preprints202208.0436.v1

Abstract

Indole and indole-3-lactate are known dominant microbial tryptophan catabolites (MICT). In obesity, the fecal indole concentration corresponds to the normal one, and that of indole-3-lactate significantly decreases along with other MICT, while it increases in blood plasma. During the analysis of the «enzymatic landscape» of the intestinal microbiota we find an almost twofold increase in the correlation between the concentrations of fecal MICT and the «enzymatic landscape», with indole-3-lactate having the closest relationships with the “enzymatic landscape” of all MICT. Here, we report statistically significant correlations of indole-3-lactate and the gut microbial enzymes for fructose, amino sugars, nucleotides, polyamines metabolism, and sulfoglycolysis. We also demonstrate that indole-3-lactate producing microbiota representatives increase three-fold in obesity. The phenotype of the microbiotic population is thus represented by completely different genera and species of microorganisms in obese individuals compared to healthy donors.

Keywords

tryptophan metabolites; microbiome; obesity; enzymatic landscape

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

Not displayed online.

Importance: How significant is the paper to the field?

Outstanding/highlight paper

Significant contribution

Incremental contribution

No contribution

I am not qualified to judge

Soundness of evidence/arguments presented:

Conclusions well supported

Most conclusions supported (minor revision needed)

Incomplete evidence (major revision needed)

Hypothesis, unsupported conclusions, or proof-of-principle

I am not qualified to judge

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Please enter a valid URL

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Please enter a valid URL

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website Send my name and email address to the authors

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)

* All users must log in before leaving a comment

what’s this?

Add a record of this review to Publons to track and showcase your reviewing expertise across the world’s journals.

Downloads 0

Comments 0

Metrics 0

Get PDF Cite Share 0

Bookmark BibSonomy Mendeley Reddit Delicious

Alerts

Notify me about updates to this article or when a peer-reviewed version is published.

Preprints.org is a free preprint server subsidized by MDPI in Basel, Switzerland.

MDPI Initiatives

SciProfiles
Sciforum
Encyclopedia
MDPI Books
Scilit
Proceedings
JAMS

Important links

How it Works
Advisory Board
FAQ
Friendly Journals
Instructions for Authors
About
Statistics

Choose the area that interest you and we will send you notifications of new preprints at your preferred frequency.

Disclaimer

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.

RSS feed for

Preprints: The Multidisciplinary Preprint Platform

Paste the URL in your RSS reader:

https://www.preprints.org/rss

If you want to subscribe our website in subject-wide, you could find the URL by choosing in the following:

https://www.preprints.org/rss

Please note that by using ScienceDirect RSS feeds, you agree to our Terms of Use and Privacy Policy.