Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Probiotic as A Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of in vitro and in vivo Studies

Chatuthanai Savigamin
,
Chatpol Samuthpongtorn
ORCID logo ,
Nuttida Mahakit
,
Tanawin Nopsopon
ORCID logo ,
Julia Heath
,
Krit Pongpirul
* ORCID logo
Version 1 : Received: 23 July 2022 / Approved: 25 July 2022 / Online: 25 July 2022 (11:37:22 CEST)

A peer-reviewed article of this Preprint also exists.

Savigamin, C.; Samuthpongtorn, C.; Mahakit, N.; Nopsopon, T.; Heath, J.; Pongpirul, K. Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies. Nutrients 2022, 14, 3661. Savigamin, C.; Samuthpongtorn, C.; Mahakit, N.; Nopsopon, T.; Heath, J.; Pongpirul, K. Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies. Nutrients 2022, 14, 3661.

Abstract

Background: Pharmacologic and non-pharmacologic treatments for stroke are essential but could be costly or harmful whereas probiotic has been a promising alternative. This scoping review aimed to synthesize the in vitro and in vivo evidence of probiotics on stroke-related neurological, biochemical, and histochemical outcomes. Method: We searched in PubMed, Embase, and Cochrane Central Register of Clinical up to May 7, 2021, and screened by two independent reviewers. We included the use of probiotics, prebiotics, and symbiotics both in vitro and in vivo for the prevention or treatment of the stroke-related model. Result: Of 6,293 articles, 4,990 passed the initial screen, of which 36 theme-related full-texts were assessed and 13 were included in this review. Probiotics could ameliorate the neurological deficit and show their property as an anti-inflammation and anti-oxidative stress. Histopathologically decreased loss of cerebral volume and inhibition of neuronal apoptosis were found. Conclusion: There are potential cognitive benefits of probiotic supplementation, especially among animal models, on decreasing cerebral volume, increasing neurological score, and decreasing the inflammatory response. However, further investigation is needed to validate these conclusions in various populations.

Keywords

probiotic; stroke; gut microbiome; meta-analysis

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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