Version 1
: Received: 9 May 2022 / Approved: 11 May 2022 / Online: 11 May 2022 (10:11:07 CEST)
How to cite:
Rempel, M.; Emberly, E. Optimizing Efficiency and Motility of A Polyvalent Molecular Motor. Preprints2022, 2022050152. https://doi.org/10.20944/preprints202205.0152.v1
Rempel, M.; Emberly, E. Optimizing Efficiency and Motility of A Polyvalent Molecular Motor. Preprints 2022, 2022050152. https://doi.org/10.20944/preprints202205.0152.v1
Rempel, M.; Emberly, E. Optimizing Efficiency and Motility of A Polyvalent Molecular Motor. Preprints2022, 2022050152. https://doi.org/10.20944/preprints202205.0152.v1
APA Style
Rempel, M., & Emberly, E. (2022). Optimizing Efficiency and Motility of A Polyvalent Molecular Motor. Preprints. https://doi.org/10.20944/preprints202205.0152.v1
Chicago/Turabian Style
Rempel, M. and Eldon Emberly. 2022 "Optimizing Efficiency and Motility of A Polyvalent Molecular Motor" Preprints. https://doi.org/10.20944/preprints202205.0152.v1
Abstract
Molecular motors play a vital role in the transport of material within the cell. A family of motors of growing interest are burnt bridge ratchets (BBRs). BBRs rectify spatial fluctuations into directed motion by creating and destroying motor-substrate bonds. It has been shown that the motility of a BBR can be optimized as a function of the system parameters. However, the amount of energy input required to generate such motion and the resulting efficiency has been less well characterized. Here, using a deterministic model, we calculate the efficiency of a particular type of BBR, namely a polyvalent hub interacting with a surface of substrate. We find that there is an optimal burn rate and substrate concentration that leads to optimal efficiency. Additionally, the substrate turnover rate has important implications on motor efficiency. We also consider the effects of force-dependent unbinding on the efficiency and find that under certain conditions the motor works more efficiently when bond breaking is included. Our results provide guidance for how to optimize the efficiency of BBRs.
Keywords
molecular motor; burnt bridge ratchet; computational model
Subject
Physical Sciences, Acoustics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
