Article Version 1 Preserved in Portico This version is not peer-reviewed
Percentages of Vaccination Coverage Required To Establish Herd Immunity Against SARS-Cov-2
Version 1 : Received: 25 April 2022 / Approved: 27 April 2022 / Online: 27 April 2022 (05:04:20 CEST)
A peer-reviewed article of this Preprint also exists.
Plans-Rubió, P. Percentages of Vaccination Coverage Required to Establish Herd Immunity against SARS-CoV-2. Vaccines 2022, 10, 736. Plans-Rubió, P. Percentages of Vaccination Coverage Required to Establish Herd Immunity against SARS-CoV-2. Vaccines 2022, 10, 736.
The pandemic associated with SARS-CoV-2 is a worldwide public health challenge. The WHO has proposed to achieve 70% COVID-19 vaccination coverage in all countries by mid-2022. Nevertheless, the prevention strategy based on COVID-19 vaccination and other applied prevention measures have not been sufficient to prevent SARS-CoV-2 epidemic waves. The study assessed the vaccination coverage that would be required to establish herd immunity against SARS-CoV-2 by taking into account virus transmissibility (Ro values from 1.1 to 10) and Covid-19 vaccination effectiveness. The study found that Covid-19 vaccination programs could establish herd immunity against SARS-CoV-2 with Ro < 3 with levels of Covid-19 vaccination effectiveness of 10−100% and against viruses with Ro values ranging from 3 to 10 with levels of Covid-19 vaccination effectiveness of 70−100%. Factors reducing Covid-19 vaccination effectiveness (emergent variants, reinfections, high risk individuals) and factors increasing SARS-CoV-2 transmissibility (close settings) increased percentages of vaccination coverage that would be required to establish herd immunity. The vaccination coverage objective of 70% could be adequate against SARS-CoV-2 with Ro values of 1.1−2.5, while percentages of vaccination coverage of 80% and 90% could be more adequate against viruses with Ro values of 2.5−3.5 and >3.5, respectively. On February 2022, the vaccination coverage for complete vaccination was lower than 70% in 73.2% of the countries of the world. Percentages of Covid-19 vaccination coverage must be increased in most countries of the world to increase individual and herd immunity levels in the population.
Covid-19 vaccination coverage; anti-SARS-CoV-2 herd immunity; Covid-19 vaccination strategy; SARS-CoV-2
MEDICINE & PHARMACOLOGY, General Medical Research
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