Preprint Concept Paper Version 2 Preserved in Portico This version is not peer-reviewed

Use of a Polypill to Reduce Cardiovascular Risk Factors in Primary and Secondary Prevention: Review and Use Guidelines

Version 1 : Received: 29 March 2022 / Approved: 31 March 2022 / Online: 31 March 2022 (10:01:28 CEST)
Version 2 : Received: 30 October 2022 / Approved: 31 October 2022 / Online: 31 October 2022 (09:27:48 CET)

How to cite: Esquirol Caussa, J.; Herrero Vila, E.; Sánchez Aldeguer, J. Use of a Polypill to Reduce Cardiovascular Risk Factors in Primary and Secondary Prevention: Review and Use Guidelines. Preprints 2022, 2022030404. https://doi.org/10.20944/preprints202203.0404.v2 Esquirol Caussa, J.; Herrero Vila, E.; Sánchez Aldeguer, J. Use of a Polypill to Reduce Cardiovascular Risk Factors in Primary and Secondary Prevention: Review and Use Guidelines. Preprints 2022, 2022030404. https://doi.org/10.20944/preprints202203.0404.v2

Abstract

Primary and secondary cardiovascular prevention is less effective than expected due to the concern about polymedication by professionals and the lack of patient adherence to medications prescribed in the medium and long term. Polypills have been presented as a possible solution. A comprehensive bibliographic review is presented about polypills as mechanisms for facilitating adherence and a proposed guide for the use of polypills for the prevention of cardiovascular risk. 41 articles were included, showing options for the polypill as a method of primary and secondary cardiovascular prevention.The polypill increases therapeutic adherence in the medium and long term, also increasing the therapeutic results compared to the administration of the various drugs separately. Based on the evidence, a flow diagram is proposed for the prescription of a polypill.Polypills increase the effectiveness and adherence of patients to primary and secondary cardiovascular prevention programs, without increasing the cost of the intervention. The use of a polypill in cardiovascular prevention can be effective as a prescription tool.

Keywords

Polypill; Cardiovascular Risk; Primary Prevention; Secondary Prevention; Adherence; Cost-effectivity

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Comments (1)

Comment 1
Received: 31 October 2022
Commenter: Jordi Esquirol Caussa
Commenter's Conflict of Interests: Author
Comment: New bibliographic references included.
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