Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Class I MHC Polymorphisms Associated with Type 2 Diabetes in Mexican Population

Paola Mendoza Ramirez
ORCID logo ,
Mildred Alejandra López-Olaiz
ORCID logo ,
Adriana Lizeth Morales-Fernandez
,
Maria Isabel Flores-Echiveste
,
Antonio de Jesus Casillas-Navarro
,
Marco Andrés Pérez-Rodríguez
,
Felipe de Jesús Orozco-Luna
,
Celso Cortés-Romero
,
Laura Yareni Zuñiga
ORCID logo ,
María Guadalupe Sanchez Parada
,
Luis Daniel Hernandez-Ortega
,
Arieh Roldan Sesma Mercado
ORCID logo ,
Raúl Cuauhtémoc Baptista Rosas
* ORCID logo
Version 1 : Received: 7 March 2022 / Approved: 15 March 2022 / Online: 15 March 2022 (03:49:43 CET)

A peer-reviewed article of this Preprint also exists.

Mendoza-Ramírez, P.; López-Olaiz, M.A.; Morales-Fernández, A.L.; Flores-Echiveste, M.I.; de Jesus Casillas-Navarro, A.; Pérez-Rodríguez, M.A.; de Jesús Orozco-Luna, F.; Cortés-Romero, C.; Zuñiga, L.Y.; Sanchez Parada, M.G.; Hernandez-Ortega, L.D.; Mercado-Sesma, A.R.; Baptista-Rosas, R.C. Class I MHC Polymorphisms Associated with Type 2 Diabetes in the Mexican Population. Genes 2022, 13, 772. Mendoza-Ramírez, P.; López-Olaiz, M.A.; Morales-Fernández, A.L.; Flores-Echiveste, M.I.; de Jesus Casillas-Navarro, A.; Pérez-Rodríguez, M.A.; de Jesús Orozco-Luna, F.; Cortés-Romero, C.; Zuñiga, L.Y.; Sanchez Parada, M.G.; Hernandez-Ortega, L.D.; Mercado-Sesma, A.R.; Baptista-Rosas, R.C. Class I MHC Polymorphisms Associated with Type 2 Diabetes in the Mexican Population. Genes 2022, 13, 772.

Abstract

Type 2 diabetes has been linked to the expression of Human Leukocyte Antigens, principally to the major Histocompatibility Complex Class II and only scarce reports to Major Histocompatibility Complex class I in specific populations. The objective of the present work was to explore the presence of polymorphisms in the MHC class I related to Type 2 diabetes in the Mexican population using the GWAS SIGMA database. This database contains information of 3,848 Mexican individuals with type 2 diabetes and 4,366 control individuals from the same population without clinical or hereditary history of the disease. The searching criteria considered a P value < 0.005 and odds ratio, OR > 1.0. Ten novel statistically significant nucleotide variants were identified: four polymorphisms associated with HLA-A (A*03:01:01:01), and six with HLA-C (C*01:02:01:01). These alleles have a high prevalence in Latin American populations and could potentially be associated with autoimmunity mechanisms related with the development of Type 2 diabetes complications.

Keywords

HLA; MHC class I; polymorphism; variant; type 2 diabetes; mexican

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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