Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Endoglin and Other Angiogenesis Markers on Recurrent Varicose Veins

Version 1 : Received: 1 March 2022 / Approved: 3 March 2022 / Online: 3 March 2022 (07:47:09 CET)

A peer-reviewed article of this Preprint also exists.

Lozano Sánchez, F.S.; Carnicero Martínez, J.A.; Méndez-García, L.; García-Cenador, M.B.; Pericacho, M. Endoglin and Other Angiogenesis Markers in Recurrent Varicose Veins. J. Pers. Med. 2022, 12, 528. Lozano Sánchez, F.S.; Carnicero Martínez, J.A.; Méndez-García, L.; García-Cenador, M.B.; Pericacho, M. Endoglin and Other Angiogenesis Markers in Recurrent Varicose Veins. J. Pers. Med. 2022, 12, 528.

Journal reference: J. Pers. Med. 2022, 12, 528
DOI: 10.3390/jpm12040528

Abstract

Abstract: Background: Surgery on varicose veins (crossectomy and stripping) leads to recurrence and has clinical and socio-economic repercussions. Their etiopathogenesis has yet to fully under-stood. Objective: Study the expression of endoglin and other molecules involved in the neovascu-larisation process in patients suffering from this disease. Methods: 43 patients that have undergone surgery for varicose veins (24 primary and 19 recurrent). They were identified on the venous wall (proximal -saphenofemoral junction- and distal), via real-time RT-PCR, and in serum, via ELISA: Endoglin (Eng), Vascular Endothelial Growth Factor (VEGF-A), its receptors 1 and 2 (VEGFR1 or FLT1), (VEGFR2 or FLK), and the Hypoxia-Inducible Factor (HIF-1A). All the patients signed a con-sent form. Results: The recurrent group recorded a higher expression of Eng, VEGF-A, VEGFR1 and VEGFR2 at the level of proximal venous wall compared to the primary group. HIF-1A did not record any differences. As regards the determination of the distal venous wall, no markers recorded differ-ences between the groups. Among the serum determinations, only sFLT1 recorded a significant drop among the patients with recurrent varicose veins. Conclusions: Patients with recurrent vari-cose veins record a higher expression of endoglin and other markers of angiogenesis in proximal veins. Endoglin in the blood (sEng) has not proven to be of any use in recurrent varicose veins.

Keywords

Varicose veins; Recurrent varicose veins; Angiogenesis; Endoglin

Subject

MEDICINE & PHARMACOLOGY, General Medical Research

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.