Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Concentrations of Ciprofloxacin in the World’s Rivers Are Associated With the Prevalence of Fluoroquinolone Resistance in E. coli: A Global Ecological Analysis

Version 1 : Received: 23 February 2022 / Approved: 24 February 2022 / Online: 24 February 2022 (10:03:48 CET)

A peer-reviewed article of this Preprint also exists.

Kenyon, C. Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in Escherichia coli: A Global Ecological Analysis. Antibiotics 2022, 11, 417. Kenyon, C. Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in Escherichia coli: A Global Ecological Analysis. Antibiotics 2022, 11, 417.

Journal reference: Antibiotics 2022, 11, 417
DOI: 10.3390/antibiotics11030417

Abstract

Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceded safe levels at 64 sites. We assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in Escherichia coli. Methods Spearman’s regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in E. coli and the median ciprofloxacin concentration in the countries rivers. Results The prevalence of fluoroquinolone resistance in E. coli was positively correlated with the concentration of ciprofloxacin in rivers (ρ=0.36; P=0.011; N=48). Conclusions Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in E. coli and other bacterial species.

Keywords

Rivers; one-health; E. coli; fluoroquinolones; antimicrobial resistance; AMR

Subject

MEDICINE & PHARMACOLOGY, Other

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.