Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Progress in Antimalarial Drug Discovery and Development: Obstructions and Opportunities

Version 1 : Received: 28 January 2022 / Approved: 4 February 2022 / Online: 4 February 2022 (10:22:34 CET)

How to cite: Naaz, R. Progress in Antimalarial Drug Discovery and Development: Obstructions and Opportunities. Preprints 2022, 2022020067 (doi: 10.20944/preprints202202.0067.v1). Naaz, R. Progress in Antimalarial Drug Discovery and Development: Obstructions and Opportunities. Preprints 2022, 2022020067 (doi: 10.20944/preprints202202.0067.v1).

Abstract

Mosquitoes conveying Plasmodium store parasites into the skin of the mammalian host. Parasites make a trip through the circulation system to the liver, where they cross a few hepatocytes prior to building up a disease. Inside the last hepatocyte the parasite goes through morphogenesis and afterward abiogenetically partitions to become more than 20,000 blood-infective parasites, called merozoites. On account of P. vivax, P. ovale, and P. cynomolgi, the parasites can stay lethargic in the liver in structures called hypnozoites. The merozoites are delivered once again into the circulation system, where they start the repetitive blood stage. Inside erythrocytes, a little division of parasites separate into male or female gametocytes. These gametocytes are ingested by the mosquito during blood taking care of, where they will duplicate explicitly, in the long run prompting the arrangement of sporozoites

Keywords

Antimalarial Drug; Malaria Vaccine; Drug Discovery; Artimisnine; K13; Malaria

Subject

BIOLOGY, Anatomy & Morphology

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