Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In-vitro and In-vivo Feasibility Study for a Mobile VV-ECMO and ECCO2R System

Lasse Johannes Strudthoff
* ORCID logo ,
Hanna Lüken
,
Sebastian Victor Jansen
,
Jan Petran
,
Peter Schlanstein
,
Lotte Schraven
,
Benjamin Josef Schürmann
,
Niklas Balduin Steuer
ORCID logo ,
Georg Wagner
,
Thomas Schmitz-Rode
,
Ulrich Steinseifer
,
Jutta Arens
ORCID logo ,
Rüdger Kopp
Version 1 : Received: 3 December 2021 / Approved: 8 December 2021 / Online: 8 December 2021 (14:16:25 CET)

A peer-reviewed article of this Preprint also exists.

Strudthoff, L.J.; Lüken, H.; Jansen, S.V.; Petran, J.; Schlanstein, P.C.; Schraven, L.; Schürmann, B.J.; Steuer, N.B.; Wagner, G.; Schmitz-Rode, T.; Steinseifer, U.; Arens, J.; Kopp, R. In Vitro and In Vivo Feasibility Study for a Portable VV-ECMO and ECCO2R System. Membranes 2022, 12, 133. Strudthoff, L.J.; Lüken, H.; Jansen, S.V.; Petran, J.; Schlanstein, P.C.; Schraven, L.; Schürmann, B.J.; Steuer, N.B.; Wagner, G.; Schmitz-Rode, T.; Steinseifer, U.; Arens, J.; Kopp, R. In Vitro and In Vivo Feasibility Study for a Portable VV-ECMO and ECCO2R System. Membranes 2022, 12, 133.

Abstract

Extracorporeal membrane oxygenation (ECMO) is an established rescue therapy for patients with chronic respiratory failure waiting for lung transplantation (LTx). The therapy inherent immobilization may result in fatigue, consecutive deteriorated prognosis and even lost eligibility for transplantation. We conducted a feasibility study on a novel system designed for the deployment of a mobile ECMO device, enabling physical exercise of awake patients prior to LTx. The system comprises a novel mobile oxygenator with a directly connected blood pump, a double lumen cannula, gas blender and supply, as well as control, and energy management. In-vitro experiments included tests regarding performance, efficiency, and blood damage. A reduced system was tested in vivo for feasibility using a novel large animal model. Six anesthetized pigs were first positioned in supine position, followed by a 45° angle, simulating an upright position of the patients. We monitored performance and vital parameters. All in-vitro experiments showed good performance for the respective subsystems and the integrated system. The acute invivo trials of 8h duration confirmed the results. The novel mobile ECMO-system enables adequate oxygenation and decarboxylation sufficient for, e.g., physical exercise of designated LTx-recipients. These results are promising and suggest further preclinical studies on safety and efficacy to facilitate translation into clinical application.

Keywords

ECMO; ECLS; ECCO2R; ARDS; respiratory failure, LTx, DIN EN ISO 7199; Extracorporeal membrane oxygenation, acute respiratory distress syndrome, animal model

Subject

Medicine and Pharmacology, Emergency Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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