Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Prospective Evaluation of Circulating miR-126, mir-197 and mir-223 in Relation to Cardiometabolic Diseases

Version 1 : Received: 5 December 2021 / Approved: 6 December 2021 / Online: 6 December 2021 (12:52:25 CET)

How to cite: Gallo, W.H.; Ottosson, F.; Kennbäck, C.; Jujic, A.; Esguerra, J.; Eliasson, L.; Melander, O. Prospective Evaluation of Circulating miR-126, mir-197 and mir-223 in Relation to Cardiometabolic Diseases. Preprints 2021, 2021120073 (doi: 10.20944/preprints202112.0073.v1). Gallo, W.H.; Ottosson, F.; Kennbäck, C.; Jujic, A.; Esguerra, J.; Eliasson, L.; Melander, O. Prospective Evaluation of Circulating miR-126, mir-197 and mir-223 in Relation to Cardiometabolic Diseases. Preprints 2021, 2021120073 (doi: 10.20944/preprints202112.0073.v1).

Abstract

We aim to investigate if serum levels of microRNAs: miR-126, mir-197 and mir-223, previously implicated in cardiometabolic disease, are reproducibly associated with incident-diabetes (inc-DM), incident-cardiovascular disease (inc-CVD) and with carotid atherosclerosis (measured for the maximum thickness of the intima-media of the carotid bulb (IMT)). The microRNAs were measured, one: in serum of 553 subjects from the baseline exam of the Swedish prospective cohort, Malmö Diet and Cancer Study (MDC-CC), with 169 subjects who developed CVD and 140 DM (16 years follow-up) and, two: in 1221 subjects from the Malmö Offspring Study (MOS), with 14 de-veloped CVD and 12 DM (3.7 years follow-up). Multivariate logistic and linear regression models were used to investigate the relationship of serum-concentrations of the microRNAs and inc-DM, inc-CVD, IMT-bulb respectively. In MDC-CC, miR-126 showed significant positive association with inc-DM (p= 0.01) whereas in fully adjusted model, the association was borderline significant (p= 0.05). The results were not replicated in MOS. There was no consistent significant association between the microRNAs with IMT or inc-CVD in any cohort. Our results do not support previous reports on significant associations between these microRNAs and the risk of CMD, as they were not reproducible in our cohorts. In addition, the directionality of any associations found were not consistent with those previously reported.

Keywords

MicroRNAs; miR-126; mir-197; mir-223; Cardiometabolic Disease; Diabetes; Cardiovascular disease; Atherosclerosis; Inter Media Thickness

Subject

LIFE SCIENCES, Endocrinology & Metabolomics

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