Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In Vitro Cytotoxic Effect of 2-(Morpholin-4-Yl)-4,5-Bis(2’’,2’’,2’’-Trinitroethoxy)-1,3,5-Triazine on Human Fibroblasts, Peripheral Blood Mononuclear Cells and Breast Cancer Cells

Version 1 : Received: 19 November 2021 / Approved: 22 November 2021 / Online: 22 November 2021 (14:18:14 CET)

How to cite: Limareva, L.; Iliasov, P.; Gidaspov, A.; Zalomlenkov, V.; Sustretov, A.; Sizova, A.; Rossinskaya, V. In Vitro Cytotoxic Effect of 2-(Morpholin-4-Yl)-4,5-Bis(2’’,2’’,2’’-Trinitroethoxy)-1,3,5-Triazine on Human Fibroblasts, Peripheral Blood Mononuclear Cells and Breast Cancer Cells. Preprints 2021, 2021110403 (doi: 10.20944/preprints202111.0403.v1). Limareva, L.; Iliasov, P.; Gidaspov, A.; Zalomlenkov, V.; Sustretov, A.; Sizova, A.; Rossinskaya, V. In Vitro Cytotoxic Effect of 2-(Morpholin-4-Yl)-4,5-Bis(2’’,2’’,2’’-Trinitroethoxy)-1,3,5-Triazine on Human Fibroblasts, Peripheral Blood Mononuclear Cells and Breast Cancer Cells. Preprints 2021, 2021110403 (doi: 10.20944/preprints202111.0403.v1).

Abstract

2-(Morpholin-4-yl)-4,5-bis(2’’,2’’,2’’-trinitroethoxy)-1,3,5-triazine having QSAR-predicted anti-tumor activity was tested for the cytotoxicity using MTT and LDH cell viability tests. The experiments were conducted using human fibroblasts, peripheral blood mononuclear cells and breast cancer cells and allowed to identify effective cytotoxic concentration ant therapeutic range of this compound. The data obtained suggest the feasibility of the further studies of the test compound as a potential anti-cancer agent.

Keywords

anticancer agent; cytotoxicity; cell viability test; QSAR

Subject

MEDICINE & PHARMACOLOGY, Pharmacology & Toxicology

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