Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Targeting the Plasmodium falciparum Proteome and Organelles for Potential Antimalarial Drug Candidates

Version 1 : Received: 8 November 2021 / Approved: 9 November 2021 / Online: 9 November 2021 (15:50:12 CET)

How to cite: Abugri, J. Targeting the Plasmodium falciparum Proteome and Organelles for Potential Antimalarial Drug Candidates. Preprints 2021, 2021110190 (doi: 10.20944/preprints202111.0190.v1). Abugri, J. Targeting the Plasmodium falciparum Proteome and Organelles for Potential Antimalarial Drug Candidates. Preprints 2021, 2021110190 (doi: 10.20944/preprints202111.0190.v1).

Abstract

There is an overarching need to find alternative treatment options for malaria and this quest is more pressing in current times due to the morbidity and mortality data arising from most endemic countries and partially owing to the fact that the SARS-Cov-2 pandemic has diverted much public health attention. Additionally, the therapeutic options available for malaria has been severely threatened with the emergence of resistance to almost all existing drugs by the human malaria parasite. The Artemisinin Combination Therapies (ACTs) which hitherto have been the mainstay for malaria have encountered resistance in South East Asia, a notorious ground zero for the emergence of antimalarial drug resistance. This review analyses few key druggable targets of the parasite and the potential to leverage strategic inhibitors to mitigate the scourge of malaria by providing a concise assessment of the essential proteins of the malaria parasite that could serve as targets. Furthermore, this work provides a summary of the advances made in malaria parasite biology and the potential to leverage such findings for antimalarial drug production.

Keywords

Malaria; proteases; Plasmodium rhomboids; dipeptidyl aminopeptidases; apical membrane antigen; subtilisin-like proteins; glucose transporters; schizogony; plasmepsins

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